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Redox Modulation of p53 Conformation and Sequence-specific DNA Binding in Vitro¹

Department of Biology, University of York, Heslington, York YO1 5DD, United Kingdom

² To whom requests for reprints should be adressed, at Department of Biology, University of York, Heslington, York YO1 5DD, United Kingdom.

The p53 protein is a transcription factor, the function of which is abrogated by oncogenic mutations which affect a flexible domain in the central portion of p53, altering its reactivity with conformation-specific antibodies. Here we show that both conformation and sequence-specific DNA binding of p53 translated in vitro can be modulated by metal chelators and oxidizing agents. Oxidation disrupted wild-type p53 conformation and inhibited DNA binding. Conversely, reduction favored folding of p53 into the wild-type form and restored DNA binding. Redox regulation of p53 protein conformation could represent an important mechanism for the control of p53 function.

¹ This work was supported by a Yorkshire Cancer Research Campaign program grant to J. M.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 7/12/93. Accepted 8/17/93.

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				A. M. Fourie, T. R. Hupp, D. P. Lane, B.-C. Sang, M. S. Barbosa, J. F. Sambrook, and M.-J. H. Gething HSP70 Binding Sites in the Tumor Suppressor Protein p53 J. Biol. Chem., August 1, 1997; 272(31): 19471 - 19479. [Abstract] [Full Text] [PDF]

				Y. Akamatsu, T. Ohno, K. Hirota, H. Kagoshima, J. Yodoi, and K. Shigesada Redox Regulation of the DNA Binding Activity in Transcription Factor PEBP2. THE ROLES OF TWO CONSERVED CYSTEINE RESIDUES J. Biol. Chem., June 6, 1997; 272(23): 14497 - 14500. [Abstract] [Full Text] [PDF]

				L Jayaraman, K G Murthy, C Zhu, T Curran, S Xanthoudakis, and C Prives Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes & Dev., March 1, 1997; 11(5): 558 - 570. [Abstract] [PDF]

				A. G. Ostermeyer, E. Runko, B. Winkfield, B. Ahn, and U. M. Moll Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide PNAS, December 24, 1996; 93(26): 15190 - 15194. [Abstract] [Full Text] [PDF]

				L J Ko and C Prives p53: puzzle and paradigm. Genes & Dev., May 1, 1996; 10(9): 1054 - 1072. [PDF]

				T. Russo, N. Zambrano, F. Esposito, R. Ammendola, F. Cimino, M. Fiscella, J. Jackman, P. M. O'Connor, C. W. Anderson, and E. Appella A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress J. Biol. Chem., December 8, 1995; 270(49): 29386 - 29391. [Abstract] [Full Text] [PDF]

				T. R. Hupp and D. P. Lane Two Distinct Signaling Pathways Activate the Latent DNA Binding Function of p53 in a Casein Kinase II-independent Manner J. Biol. Chem., July 28, 1995; 270(30): 18165 - 18174. [Abstract] [Full Text] [PDF]

				J. S. Lazo, Y. Kondo, D. Dellapiazza, A. E. Michalska, K. H. A. Choo, and B. R. Pitt Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes J. Biol. Chem., March 10, 1995; 270(10): 5506 - 5510. [Abstract] [Full Text] [PDF]

				A. Di Leonardo, S.P. Linke, Y. Yin, and G.M. Wahl Cell Cycle Regulation of Gene Amplification Cold Spring Harb Symp Quant Biol, January 1, 1993; 58(0): 655 - 667. [Abstract] [PDF]

				R. S. Arnold, J. Shi, E. Murad, A. M. Whalen, C. Q. Sun, R. Polavarapu, S. Parthasarathy, J. A. Petros, and J. D. Lambeth Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1 PNAS, May 8, 2001; 98(10): 5550 - 5555. [Abstract] [Full Text] [PDF]

				P. J. Moos, K. Edes, and F. A. Fitzpatrick Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins PNAS, August 1, 2000; 97(16): 9215 - 9220. [Abstract] [Full Text] [PDF]