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Otolaryngology-Head and Neck Surgery [J. O. B., J. H., W. K., P. v. d. R., R. A. R., Y. J. E., J. M. R., D. S.] and Department of Oral Surgery [R. C.] the Johns Hopkins University, and Department of Pathology [R. H. H.], the Johns Hopkins Hospital, Baltimore, Maryland 21205
2 To whom requests for reprints should be addressed.
To establish a genetic model of the progression of head and neck squamous carcinoma we have defined the incidence and timing of p53 mutations in this type of cancer. We sequenced the conserved regions of the p53 gene in 102 head and neck squamous carcinoma lesions. These included 65 primary invasive carcinomas and 37 noninvasive archival specimens consisting of 13 severe dysplasias and 24 carcinoma in situ lesions. The incidence of p53 mutations in noninvasive lesions was 19% (7/37) and increased to 43% (28/65) in invasive carcinomas. These data suggest that p53 mutations can precede invasion in primary head and neck cancer. Furthermore, the spectrum of codon hotspots is similar to that seen in squamous carcinoma of the lung and 64% of mutations are at G nucleotides, implicating carcinogens from tobacco smoke in the etiology of head and neck squamous carcinoma.
1 This work was supported by NCI CORE Grant CA58184-01.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received 7/21/93. Accepted 8/19/93.
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J. A. Brennan, L. Mao, R. H. Hruban, J. O. Boyle, Y. J. Eby, W. M. Koch, S. N. Goodman, and D. |
