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Chromosome Mapping of Murine Susceptibility Loci to Liver Carcinogenesis¹

Division of Experimental Oncology A, Istituto Nazionale Tumori [M. G., G. M., F. C., F S. F., M. A. P, G. D. P., T. A. D.], and Department of Genetics and Microbiology, University of Milan [G. B.], Milan, Italy

² To whom requests for reprints should be addressed, at Istituto Nazionale Tumori, Via G. Venezian 1, 20133, Milan, Italy.

The validity of mouse liver tumors is controversial in the risk assessment of carcinogenicity of chemicals in humans, because mice used in carcinogenicity bioassays are genetically predisposed to liver tumors. The argument could be resolved once liver tumor susceptibility genes have been cloned and their role in liver tumor development elucidated. We performed a genetic linkage analysis to map murine liver tumor susceptibility genes, as a first step toward their identification. An F2 population of 87 urethane-treated male A/J x C3H/He mice was scored with 83 genetic markers. Three regions, localized on chromosomes 7, 8, and 12, were found to contain putative liver tumor susceptibility genes.

¹ Supported in part by grants from the Finalized Project "ACRO" of the Italian National Research Council and Associazione Italiana Ricerca Cancro.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 8/ 6/92. Accepted 11/25/92.

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