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Prevention of Carcinogenicity of Anticancer Drugs by Metallothionein Induction¹

Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo 105 [M. S.]; Department of Public Health [M. S., I. N., A. N., N. I.] and Laboratory Animal Research Center [M. M.], School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108; and Department of Urology, Nippon Medical School, Bunkyo-ku, Tokyo 113 [Y. K.], Japan

We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.

¹ Supported by Grant-in-Aid 04253240 for Special Project Research, Cancer-Bioscience, from the Ministry of Education, Science, and Culture, Japan.

² On leave from Kyorin Pharmaceutical Co., Ltd.

³ To whom requests for reprints should be addressed.

Received 7/30/93. Accepted 9/ 2/93.

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