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Expression of the Tumor Suppressor Gene DCC in Human Gliomas¹

Neuro-Oncology Research [A. C. S.] and Department of Neuropathology [S. W. C.], Barrow Neurological Institute of St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013

² To whom requests for reprints should be addressed, at Neuro-Oncology Research, Barrow Neurological Institute of St. Joseph's Hospital and Medical Center, 350 West Thomas Rd., Phoenix, AZ 85013.

Reduced expression and/or allelic loss of the putative tumor suppressor gene DCC has been demonstrated in colorectal, gastric, pancreatic, esophageal, breast, and hematological malignancies. We examined the expression of the DCC gene in 22 tissue samples from human gliomas (glioblastoma multiforme, oligodendroglioma, and mixed oligodendroglioma/astrocytoma). Seven of 8 glioblastomas multiforme (88%) had reduced or absent DCC expression, and 8 of the other 14 tumors underexpressed DCC when compared to normal brain tissue. These results demonstrate that reduced expression of DCC occurs in human malignant gliomas and may be part of a common genetic pathway leading to neoplastic transformation and/or tumor progression.

¹ This work was supported by NIH Grants CA 50931 and CA 25956.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 9/ 7/93. Accepted 10/19/93.

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