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Department of Experimental Pathology, Cancer Institute, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan [O. H., H. M.], and Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111 [A. G. K.]
N-Ethyl-N-nitrosourea-induced transplacental renal carcinogenesis in the rat results primarily in Wilms' tumors, apparently because primitive nephroblasts are the preferred target. Our question is whether N-ethyl-N-nitrosourea-induced mutations in the fetal kidney would increase the number of adult-type renal cell carcinomas in the Eker rat, which is heterozygous for a mutation that predisposes to renal cell carcinoma. Surprisingly, renal cell tumors but no Wilms' tumors began to appear from as early as 1 week after birth. Thus, the inheritance of a renal cell carcinoma mutation determines the specificity of tumor histology even with in utero carcinogenesis.
1 This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science, and Culture of Japan.
2 To whom requests for reprints should be addressed.
Received 9/27/93. Accepted 11/ 2/93.
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