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Expression of Sulfated Glycoprotein 2 Is Associated with Carcinogenesis Induced by N-Nitroso-N-methylurea in Rat Prostate and Seminal Vesicle

Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892 [K. K., M. A. A., T. S. W., J. M. S., M. B. S.], and Armed Forces Institute of Pathology, Washington, DC [M. V. S.]

To understand the molecular mechanism of carcinogenesis in androgen-dependent tumors, we have searched for new markers which are associated with this process. In normal rat prostate and seminal vesicle, sulfated glycoprotein 2 (SGP-2) messenger RNA is barely detectable. However, we have found high levels of SGP-2 expression in the epithelial component of carcinomas of the prostate and seminal vesicle after initiation with N-nitroso-N-methylurea and promotion with testosterone propionate. We have also observed induction of SGP-2 expression in epithelial cells at early stages in carcinogenesis when cytologically malignant cells first begin to appear. SGP-2 has been reported previously to be associated with a variety of models of programmed cell death (apoptosis), including the prostate following castration. Our present findings provide a novel marker for carcinogenesis in the rat prostate and seminal vesicle.

¹ To whom requests for reprints should be addressed, at Laboratory of Chemoprevention, National Cancer Institute, Building 41, Room C-629, Bethesda, MD 20892.

Received 1/26/93. Accepted 2/18/93.

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