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CRC Molecular and Cellular Pharmacology Group, Manchester University School of Biological Sciences, Oxford Road, Manchester M13 9PT [C. A. E., C. D.], and Department of Biochemistry, University of Manchester Institute of Science and Technology, Sackville Street, Manchester, M60 1QD [P. J. O., A. D. W.], United Kingdom
A chromosomal translocation uniquely associated with chronic myeloid leukemia leads to the formation of a chimeric gene, bcr-abl, on the Philadelphia chromosome. The BRC-ABL protein displays an uncontrolled tyrosine kinase activity similar to that seen with the transforming oncogene of the Abelson murine leukemia (ABL) virus (v-abl). An interleukin 3 dependent cell line, IC.DP, has been transfected with a gene encoding a temperature sensitive v-ABL. In the absence of interleukin 3 at the restrictive temperature for ABL tyrosine kinase activity IC.DP cells died via apoptosis. At the permissive temperature ABL tyrosine kinase activity promoted IC.DP cell survival but not proliferation. ABL therefore can specifically suppress apoptosis.
1 This work was supported by The Cancer Research Campaign, UK and by The Leukaemia Research Fund, UK.
2 To whom requests for reprints should be addressed.
Received 1/19/93. Accepted 3/ 5/93.
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