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Departments of Pediatrics [N. L] and Pathology and Laboratory Medicine [M. K.], University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104; Simmons Cancer Center [J. M.], University of Texas, Southwestern Medical Center Dallas, Texas 75235; and Department of Medical Genetics [Y T.], Biochemical Research Center, Osaka University, Medical School, Suita, Osaka 565, Japan
2 To whom requests for reprints should be addressed, at Division of Oncology, Room 9097A-1, Children's Hospital of Philadelphia, PA 19104.
We have investigated the expression of bcl-2 protein in a panel of small cell lung carcinoma (SCLC) cells lines. Five of six cell lines examined expressed relatively high levels of bcl-2 protein and transcripts. The bcl-2 expression in SCLC cells, however, was not always associated with myc expression. Since dysregulation of bcl-2 may be involved in the course of tumorigenesis and/or in the acquisition of drug resistance of tumor cells, the expression of bcl-2 in SCLC cells may become an important indicator in the prognosis or treatment of SCLC.
1 This work was supported by Children's Cancer Research Foundation, Philadelphia, Ronald McDonald's Children's Charities, and Lucille Markey Charitable Trust.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received 8/ 6/93. Accepted 11/12/93.
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