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Departments of Urology [G. N. T., P. E. A., S-M. C., H. Y. E. Z., A. C. v. E., L. W. K. C.], Nuclear Medicine [E. E. K.], and Cell Biology [V. L. H., S. P.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
Our laboratory has previously reported on the derivation of LNCaP cell sublines from LNCaP tumors maintained in castrated and intact athymic male mice. These LNCaP sublines differ from the parental line in tumorigenicity and androgen dependence. This paper demonstrates that one of these sublines acquired metastatic potential. When inoculated either s.c. or orthotopically, the C4-2 subline metastasized to the lymph node and bone with an incidence of 11–50%. Interestingly, the incidence of osseous metastasis was higher in castrated than in intact male hosts. We evaluated the chromosomal, immunohistochemical, and biochemical characteristics of the LNCaP sublines derived from C4-2 tumors that metastasized to the lymph node and bone. Cytogenetic analysis showed that all sublines were human and shared common marker chromosomes with the parental LNCaP cells. This experimental human prostate cancer model may permit, for the first time, the study of the molecular mechanisms underlying human prostate cancer metastasis.
1 This work was supported in part by NIH Grants CA-56307 and DK-38649.
2 G. N. T. was financially supported by a scholarship from the Swiss National Foundation.
3 Present address: Department of Urology, University Hospital, 6 Esperidon Str., 71307 Heraclion, Crete, Greece.
4 To whom requests for reprints should be addressed, at Urology Research Laboratory, Box 26, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030.
Received 2/23/94. Accepted 4/ 5/94.
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