This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Otto, T. Articles by Raz, A. Search for Related Content PubMed PubMed Citation Articles by Otto, T. Articles by Raz, A.

Inverse Relation of E-Cadherin and Autocrine Motility Factor Receptor Expression as a Prognostic Factor in Patients with Bladder Carcinomas¹

Department of Urology [T. O., A. H., H. R.], Institute of Cell Biology (Tumor Research) [W. B.], Institute of Pathology [U. S.], Department of Otorhinolaryngology [J. S.], University of Essen, Medical School, Hufelandstr. 55, 4300 Essen, Federal Republic of Germany, and Metastasis Research Program, Michigan Cancer Foundation, Departments of Pathology and Radiation Oncology, Wayne State University, Detroit, Michigan 48201 [A. R.]

Down-regulation of E-cadherin, an intercellular adhesion molecule, and up-regulation of autocrine motility factor receptor (gp78) expressions have been shown to play a role in tumor cell invasion and metastasis. Monoclonal antibodies against E-cadherin and gp78 were used to stain serial snap-frozen sections of 12 normal bladder and 83 bladder carcinoma specimens (27 noninvasive, 53 invasive, and 3 metastases). In normal urothelium, E-cadherin is expressed while gp78 is not. Positive expression of E-cadherin and negative expression of gp78 were found to be associated with a low risk of clinical progression in the superficial bladder carcinoma patient group. While reduction in E-cadherin concomitantly with an increase in gp78 expression was associated with poor prognosis, 71% of the patients (n = 30) underwent rapid cancer progression, and 32% of the patients died of cancer-related disease at a median of 2 years after initial diagnosis. Thus, it is suggested that reduction of E-cadherin expression associated with an increase in the level of gp78 in bladder cancers may define a high risk group of patients. The dual use of these two antigens may improve early diagnosis of high risk bladder cancer patients and influence treatment decisions.

¹ This work was supported by Deutsche Forschungsgemeinschaft SFB 354 (to T. O., W. B., and H. R.), the Wilhelm Sander-Stiftung (to W. B.), and in part by USPHS Grant 51714 from the National Cancer Institute and the Paul Zuckerman Support Foundation for Cancer Research (to A. R.).

² Present address: Max Delbruck Cancer Center, Robert-Rossler St., 10, 12132 Berlin, Federal Republic of Germany.

³ To whom requests for reprints should be addressed, at Metastasis Research Program, Michigan Cancer Foundation, 110 East Warren Avenue, Detroit, MI 48201.

Received 3/23/94. Accepted 5/ 4/94.

This article has been cited by other articles:

				L. D. Kojic, B. Joshi, P. Lajoie, P. U. Le, M. E. Cox, D. A. Turbin, S. M. Wiseman, and I. R. Nabi Raft-dependent Endocytosis of Autocrine Motility Factor Is Phosphatidylinositol 3-Kinase-dependent in Breast Carcinoma Cells J. Biol. Chem., October 5, 2007; 282(40): 29305 - 29313. [Abstract] [Full Text] [PDF]

				T. Funasaka, H. Hu, T. Yanagawa, V. Hogan, and A. Raz Down-Regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Results in Mesenchymal-to-Epithelial Transition of Human Lung Fibrosarcoma Cells Cancer Res., May 1, 2007; 67(9): 4236 - 4243. [Abstract] [Full Text] [PDF]

				M. Amraei, Z. Jia, P. Reboul, and I. R. Nabi Acid-induced Conformational Changes in Phosphoglucose Isomerase Result in Its Increased Cell Surface Association and Deposition on Fibronectin Fibrils J. Biol. Chem., October 3, 2003; 278(40): 38935 - 38941. [Abstract] [Full Text] [PDF]

				P. U. Le, G. Guay, Y. Altschuler, and I. R. Nabi Caveolin-1 Is a Negative Regulator of Caveolae-mediated Endocytosis to the Endoplasmic Reticulum J. Biol. Chem., January 25, 2002; 277(5): 3371 - 3379. [Abstract] [Full Text] [PDF]

				M. Kara, Y. Ohta, Y. Tanaka, M. Oda, and Y. Watanabe Autocrine motility factor receptor expression in patients with stage I non-small cell lung cancer Ann. Thorac. Surg., March 1, 2001; 71(3): 944 - 948. [Abstract] [Full Text] [PDF]

				M.-Y. Hsu, F. E. Meier, M. Nesbit, J.-Y. Hsu, P. Van Belle, D. E. Elder, and M. Herlyn E-Cadherin Expression in Melanoma Cells Restores Keratinocyte-Mediated Growth Control and Down-Regulates Expression of Invasion-Related Adhesion Receptors Am. J. Pathol., May 1, 2000; 156(5): 1515 - 1525. [Abstract] [Full Text] [PDF]

				E. Pötter, C. Bergwitz, and G. Brabant The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues Endocr. Rev., April 1, 1999; 20(2): 207 - 239. [Abstract] [Full Text]

				N. Benlimame, P. U. Le, and I. R. Nabi Localization of Autocrine Motility Factor Receptor to Caveolae and Clathrin-independent Internalization of Its Ligand to Smooth Endoplasmic Reticulum Mol. Biol. Cell, July 1, 1998; 9(7): 1773 - 1786. [Abstract] [Full Text]

				I. R. Nabi, G. Guay, and D. Simard AMF-R Tubules Concentrate in a Pericentriolar Microtubule Domain After MSV Transformation of Epithelial MDCK Cells J. Histochem. Cytochem., October 1, 1997; 45(10): 1351 - 1364. [Abstract] [Full Text] [PDF]

				F Monier-Gavelle and J. Duband Control of N-cadherin-mediated intercellular adhesion in migrating neural crest cells in vitro J. Cell Sci., January 12, 1995; 108(12): 3839 - 3853. [Abstract] [PDF]