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Divisions of Biology [R. S., M. N., J. Y.], Epidemiology [N. Y.], and Pathology [M. S., S. H.], National Cancer Center Research Institute, Tokyo 104, and Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807 [H. K.], Japan
8-Hydroxydeoxyguanosine (oh8dG) is a promutagenic DNA lesion produced by oxygen radicals. We examined alterations in the oh8dG level in human livers which have chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The oh8dG content in livers with chronic hepatitis was significantly higher than the oh8dG content in normal livers (P < 0.05). There was also a significant correlation between the oh8dG content in noncancerous liver tissues with individual serum alanine aminotransferase concentration (r = 0.515; P < 0.001). thus, chronic inflammation in the liver produces oxidative DNA damage, which may increase the risk for genomic alterations causing hepatocarcinogenesis.
1 This work was supported in part by a Grant-in-Aid from the Ministry of Health and Welfare for a Comprehensive 10-year Strategy for Cancer Control and Grants-in-Aid from the Ministry of Health and Welfare and from the Ministry of Education, Science and Culture of Japan. R. S. is a recipient of Research Resident Fellowships from the Foundation for Promotion of Cancer Research.
2 To whom requests for reprints should be addressed.
Received 1/21/94. Accepted 4/20/94.
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