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[Cancer Research 54, 3396-3397, July 1, 1994]
© 1994 American Association for Cancer Research
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Frequent Somatic Mutation of the MTS1/CDK4I (Multiple Tumor Suppressor/Cyclin-dependent Kinase 4 Inhibitor) Gene in Esophageal Squamous Cell Carcinoma1

Takahiro Mori, Koh Miura, Takahisa Aoki, Tetsuro Nishihira, Shozo Mori and Yusuke Nakamura2

Department of Biochemistry, Cancer Institute, I-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170 [T. M., K. M., T. A., Y. N.], and Second Department of Surgery, Tohoku University School of Medicine, Sendai 980 [T. M., T. N., S. M.], Japan

We previously reported frequent loss of heterozygosity on chromosome 9p in esophageal carcinomas and suggested that a tumor suppressor gene located on this chromosomal arm might be involved in development of these cancers. Since recently published studies have shown that a gene mapped on chromosome 9p21, MTS1/CDK4I (multiple tumor suppressor 1/cyclin-dependent kinase 4 inhibitor), is frequently mutated in various types of tumors, we chose to examine esophageal squamous cell carcinomas for mutations in this candidate gene. DNA sequence analyses revealed somatic mutations of MTS1/CDK4I in 14 of 27 tumors examined; 8 were frame-shift mutations and 6 were missense mutations. These results suggested that the MTS1/CDK4I gene is a tumor suppressor the inactivation of which plays an important role during carcinogenesis of the squamous cell type of esophageal carcinoma.

1 This work was supported by a Grant-in-Aid from the Ministry of Science, Culture, and Education, Japan.

2 To whom requests for reprints should be addressed.

Received 5/ 9/94. Accepted 5/16/94.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1994 by the American Association for Cancer Research.