| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Laboratory for Cancer Research, Department of Chemical Biology and Pharmacognosy [Z. Y. W., M-T. H., Y-R. L., J-G. X., H. L. N., C. S. Y., A. H. C.] and Pharmacology and Taxicology [K. R. R.], College of Pharmacy, Rutgers, State University of New Jersey, Piscataway, New Jersey 08855-0789, and Department of Food Science, Cook College, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901 [C-T. H.]
In a previous study (Z. Y. Wang et al., Cancer Res., 52: 1162–1170, 1992), we found that administration of a water extract of green tea leaves as the sole source of drinking fluid inhibited ultraviolet B light (UVB)-induced carcinogenesis in SKH-1 mice previously initiated with 7,12-dimethylbenz[a]anthracene (DMBA). In the present study, we compared the effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on UVB-induced skin carcinogenesis in DMBA-initiated SKH-1 mice. A 1.25% water extract of each kind of tea leaf (1.25 g tea leaf/100 ml water) was prepared by passing 4 liters of hot water through 50 g of tea leaves in a Bunn tea brewing machine. The mean concentrations of solids in multiple samples of 1.25% black tea, green tea, decaffeinated black tea, and decaffeinated green tea analyzed during the course of this study were 4.23, 3.94, 3.66, and 3.53 mg/ml, respectively. These concentrations of tea solids are similar to those present in tea brews ingested by humans. Femmale SKH-1 mice were treated topically with 200 nmol of DMBA, followed 3 weeks later by irradiation with 30 mJ/cm2 of UVB twice weekly for 31 weeks. UVB-induced formation of skin tumors was markedly inhibited by oral administration of 0.63 or 1.25% black tea, green tea, decaffeinated black tea, or decaffeinated green tea as the sole source of drinking fluid 2 weeks prior to and during 31 weeks of UVB treatment. Administration of each of the eight tea preparations not only inhibited the number of tumors, but tumor size was also markedly decreased. Histopathological examination of each tumor showed that oral administration of the eight tea preparations had a marked inhibitory effect on the formation of UVB-induced keratoacanthomas and carcinomas. Administration of 1.25% black tea, green tea, decaffeinated black tea, or decaffeinated green tea inhibited the number of keratoacanthomas per mouse by 79, 78, 73, or 70%, respectively, and the number of carcinomas per mouse was inhibited by 93, 88, 77, or 72%, respectively. In summary, administration of black tea was comparable to green tea as an inhibitor of UVB-induced skin carcinogenesis in DMBA-initiated SKH-1 mice. Oral administration of decaffeinated black tea or decaffeinated green tea also had a marked inhibitory effect on UVB-induced skin carcinogenesis in DMBA-initiated SKH-1 mice, but these tea preparations were slightly less effective than the regular teas at the high dose level.
1 This study was supported in part by Grants No. CA49756 and ES05022 from the National Institutes of Health.
2 William M. and Myrle W. Garbe Professor of Cancer and Leukemia Research.
3 To whom requests for reprints should be addressed, at Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, P.O. Box 789, Piscataway, NJ 08855-0789.
Received 1/28/94. Accepted 4/28/94.
This article has been cited by other articles:
|
|
 |
|
  Y.-P. Lu, Y.-R. Lou, Q.-Y. Peng, J.-G. Xie, P. Nghiem, and A. H. Conney Effect of Caffeine on the ATR/Chk1 Pathway in the Epidermis of UVB-Irradiated Mice Cancer Res., April 1, 2008; 68(7): 2523 - 2529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-L. Sun, J.-M. Yuan, W. P. Koh, H.-P. Lee, and M. C. Yu Green tea and black tea consumption in relation to colorectal cancer risk: the Singapore Chinese Health Study Carcinogenesis, October 1, 2007; 28(10): 2143 - 2148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-P. Lu, Y.-R. Lou, B. Nolan, Q.-Y. Peng, J.-G. Xie, G. C. Wagner, and A. H. Conney Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice PNAS, October 31, 2006; 103(44): 16301 - 16306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Siddiqui, N. Zaman, M. H. Aziz, S. R. Reagan-Shaw, S. Sarfaraz, V. M. Adhami, N. Ahmad, S. Raisuddin, and H. Mukhtar Inhibition of CWR22R{nu}1 tumor growth and PSA secretion in athymic nude mice by green and black teas Carcinogenesis, April 1, 2006; 27(4): 833 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Yuan, W.-P. Koh, C.-L. Sun, H.-P. Lee, and M. C. Yu Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore Carcinogenesis, August 1, 2005; 26(8): 1389 - 1394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Qanungo, M. Das, S. Haldar, and A. Basu Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells Carcinogenesis, May 1, 2005; 26(5): 958 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Yoxall, M. Umachandran, J. Wilson, P. Kentish, and C. Ioannides Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat Mutagenesis, January 1, 2005; 20(1): 23 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-P. Lu, Y.-R. Lou, Q.-Y. Peng, J.-G. Xie, and A. H. Conney Stimulatory Effect of Topical Application of Caffeine on UVB-Induced Apoptosis in the Epidermis of p53 and Bax Knockout Mice Cancer Res., July 15, 2004; 64(14): 5020 - 5027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Estensen, M. M. Jordan, T. S. Wiedmann, A. R. Galbraith, V. E. Steele, and L. W. Wattenberg Effect of chemopreventive agents on separate stages of progression of benzo[{alpha}]pyrene induced lung tumors in A/J mice Carcinogenesis, February 1, 2004; 25(2): 197 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Conney Enzyme Induction and Dietary Chemicals as Approaches to Cancer Chemoprevention: The Seventh DeWitt S. Goodman Lecture Cancer Res., November 1, 2003; 63(21): 7005 - 7031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Vayalil, C. A. Elmets, and S. K. Katiyar Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin Carcinogenesis, May 1, 2003; 24(5): 927 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Catterall, E. Copeland, M. N. Clifford, and C. Ioannides Effects of black tea theafulvins on aflatoxin B1 mutagenesis in the Ames test Mutagenesis, March 1, 2003; 18(2): 145 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Matsunaga, T. W. Klein, H. Friedman, and Y. Yamamoto Epigallocatechin Gallate, a Potential Immunomodulatory Agent of Tea Components, Diminishes Cigarette Smoke Condensate-Induced Suppression of Anti-Legionella pneumophila Activity and Cytokine Responses of Alveolar Macrophages Clin. Vaccine Immunol., July 1, 2002; 9(4): 864 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Bedi and P. D. Shenefelt Herbal Therapy in Dermatology Arch Dermatol, February 1, 2002; 138(2): 232 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-P. Lu, Y.-R. Lou, Y. Lin, W. J. Shih, M.-T. Huang, C. S. Yang, and A. H. Conney Inhibitory Effects of Orally Administered Green Tea, Black Tea, and Caffeine on Skin Carcinogenesis in Mice Previously Treated with Ultraviolet B Light (High-Risk Mice): Relationship to Decreased Tissue Fat Cancer Res., July 1, 2001; 61(13): 5002 - 5009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shahrzad, K. Aoyagi, A. Winter, A. Koyama, and I. Bitsch Pharmacokinetics of Gallic Acid and Its Relative Bioavailability from Tea in Healthy Humans J. Nutr., April 1, 2001; 131(4): 1207 - 1210. [Abstract] [Full Text]
|
|
|
|
|
|
G. Caderni, C. De Filippo, C. Luceri, M. Salvadori, A. Giannini, A. Biggeri, S. Remy, V. Cheynier, and P. Dolara Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats Carcinogenesis, November 1, 2000; 21(11): 1965 - 1969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Budiyanto, N. U. Ahmed, A. Wu, T. Bito, O. Nikaido, T. Osawa, M. Ueda, and M. Ichihashi Protective effect of topically applied olive oil against photocarcinogenesis following UVB exposure of mice Carcinogenesis, November 1, 2000; 21(11): 2085 - 2090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Katiyar, A. Perez, and H. Mukhtar Green Tea Polyphenol Treatment to Human Skin Prevents Formation of Ultraviolet Light B-induced Pyrimidine Dimers in DNA Clin. Cancer Res., October 1, 2000; 6(10): 3864 - 3869. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-P. Lu, Y.-R. Lou, X. H. Li, J. G. Xie, D. Brash, M.-T. Huang, and A. H. Conney Stimulatory Effect of Oral Administration of Green Tea or Caffeine on Ultraviolet Light-induced Increases in Epidermal Wild-Type p53, p21(WAF1/CIP1), and Apoptotic Sunburn Cells in SKH-1 Mice Cancer Res., September 1, 2000; 60(17): 4785 - 4791. [Abstract] [Full Text]
|
|
|
|
|
|
J. Mimoto, K. Kiura, K. Matsuo, T. Yoshino, I. Takata, H. Ueoka, M. Kataoka, and M. Harada (-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice Carcinogenesis, May 1, 2000; 21(5): 915 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Yang, J. Y. Chung, G.-y. Yang, S. K. Chhabra, and M.-J. Lee Tea and Tea Polyphenols in Cancer Prevention J. Nutr., February 1, 2000; 130(2): 472 - 472. [Abstract] [Full Text]
|
|
|
|
|
|
S. K. Katiyar, A. Challa, T. S. McCormick, K. D. Cooper, and H. Mukhtar Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production Carcinogenesis, November 1, 1999; 20(11): 2117 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kramer-Stickland, A. Edmonds, W. B. Bair III, and G.T. Bowden Inhibitory effects of deferoxamine on UVB-induced AP-1 transactivation Carcinogenesis, November 1, 1999; 20(11): 2137 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. August, J. Landau, D. Caputo, J. Hong, M.-J. Lee, and C. S. Yang Ingestion of Green Tea Rapidly Decreases Prostaglandin E2 Levels in Rectal Mucosa in Humans Cancer Epidemiol. Biomarkers Prev., August 1, 1999; 8(8): 709 - 713. [Abstract] [Full Text]
|
|
|
|
|
|
T. Minamoto, M. Mai, and Z.'e. Ronai Environmental factors as regulators and effectors of multistep carcinogenesis Carcinogenesis, April 1, 1999; 20(4): 519 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Crawford, E. A. Kirk, M. E. Rosenfeld, R. C. LeBoeuf, and A. Chait Dietary Antioxidants Inhibit Development of Fatty Streak Lesions in the LDL Receptor–Deficient Mouse Arterioscler Thromb Vasc Biol, September 1, 1998; 18(9): 1506 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Huang, W.-Y. Ma, D. Hanenberger, M. P. Cleary, G. T. Bowden, and Z. Dong Inhibition of Ultraviolet B-induced Activator Protein-1 (AP-1) Activity by Aspirin in AP-1-Luciferase Transgenic Mice J. Biol. Chem., October 17, 1997; 272(42): 26325 - 26331. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
