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Common Regions of Deletion in Chromosome Regions 3p12 and 3p14.2 in Primary Clear Cell Renal Carcinomas¹

Department of Genetics and Pathology [J. L., P. H., J. P., A. T.] and Urology [A. S.], Medical Academy Szczecin, Poland, and Department of Pathology [P. M.] and Jefferson Cancer Institute [T. D., K. H.], Jefferson Medical College, Philadelphia, Pennsylvania 19107

Nearly all clear cell renal cell carcinomas (RCCs) exhibit loss of alleles on the short arm of chromosome 3. Loss and mutation at the von Hippel-Lindau (VHL) gene at 3p25 probably occurs in most RCCs and, since the VHL gene was recently cloned, data on VHL involvement in RCCs is accumulating. However, the region 3p14-p12, a region that contains the famillal RCC-associated t(3;8)(p14.2;q24) chromosome translocation and the small cell lung carcinoma-associated homozygous deletion at 3p13-12, has also been reported to exhibit allele loss in a large fraction of RCCs. In order to focus future studies on potential suppressor genes in the 3p14-p12 region, we have studied allele loss in 30 RCCs with 9 polymorphic simple sequence repeat markers spanning 3p21.1-p12. Partial losses in the 3p21-p12 region were observed, allowing determination of common regions of loss of heterozygosity overlap in 15 RCCs. Results suggested that most RCCs exhibit loss in a region which brackets the t(3;8) familial chromosome translocation at 3p14.2, and some show additional deletions within the U2020 small cell lung carcinoma deletion at 3p12.

¹ This work was supported by U.S.-Poland MCSJFII Grant MZ/HHS-91-75, the Polish National Scientific Committee Grant 408899101, European Communities Programme Grant BMH1-CT-0156, USPHS Grant CA51083, and a gift from the Carpenter Foundation.

² To whom requests for reprints should be addressed, at Jefferson Cancer Institute, Bluemle Life Sciences Building, Room 1008, 233 S. 10th Street, Jefferson Medical College, Philadelphia, PA 19107.

Received 4/19/94. Accepted 5/27/94.

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