Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 54, 3714-3717, July 15, 1994]
© 1994 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pietenpol, J. A.
Right arrow Articles by Vogelstein, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pietenpol, J. A.
Right arrow Articles by Vogelstein, B.

Paradoxical Inhibition of Solid Tumor Cell Growth by bcl21

Jennifer A. Pietenpol2, Nickolas Papadopoulos, Sanford Markowitz, James K. V. Willson, Kenneth W. Kinzler and Bert Vogelstein

The Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 [J. A. P., N. P., K. W. K., B. V.], and Ireland Cancer Center, University Hospitals of Cleveland, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 [S. M., J. K. V. W.]

The BCL2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. We report an unexpected effect of bcl2 expression on the in vitro growth of several solid tumor cell lines. Expression of bcl2 in these cell lines resulted in growth inhibition similar to that seen with p53. In contrast, a COOH-terminal deletion mutant of bcl2 was unable to suppress growth. Thus, the bcl2 protein may exert distinct biological effects in different cell types.

1 This work was supported by the Preuss Foundation, the Clayton Fund, the National Foundation for Cancer Research, and NIH Grants CA35494 and CA09243. B. V. is an American Cancer Society research professor.

2 To whom requests for reprints should be addressed, at The Johns Hopkins Oncology Center, 424 North Bond St., Baltimore, MD 21231.

Received 4/21/94. Accepted 6/ 1/94.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
G. M. Callagy, P. D. Pharoah, S. E. Pinder, F. D. Hsu, T. O. Nielsen, J. Ragaz, I. O. Ellis, D. Huntsman, and C. Caldas
Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index
Clin. Cancer Res., April 15, 2006; 12(8): 2468 - 2475.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. M. Garrity, L. J. Burgart, M. R. Mahoney, H. E. Windschitl, M. Salim, M. Wiesenfeld, J. E. Krook, J. C. Michalak, R. M. Goldberg, M. J. O'Connell, et al.
Prognostic Value of Proliferation, Apoptosis, Defective DNA Mismatch Repair, and p53 Overexpression in Patients With Resected Dukes' B2 or C Colon Cancer: A North Central Cancer Treatment Group Study
J. Clin. Oncol., May 1, 2004; 22(9): 1572 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Haughn, R. G. Hawley, D. K. Morrison, H. von Boehmer, and D. M. Hockenbery
BCL-2 and BCL-XL Restrict Lineage Choice during Hematopoietic Differentiation
J. Biol. Chem., June 27, 2003; 278(27): 25158 - 25165.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
K. Hiraoka, T. Morikawa, T. Ohbuchi, and H. Katoh
Solitary fibrous tumors of the pleura: clinicopathological and immunohistochemical examination
Interactive CardioVascular and Thoracic Surgery, March 1, 2003; 2(1): 61 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Decary, J. T. Decesse, V. Ogryzko, J. C. Reed, I. Naguibneva, A. Harel-Bellan, and C. E. Cremisi
The Retinoblastoma Protein Binds the Promoter of the Survival Gene bcl-2 and Regulates Its Transcription in Epithelial Cells through Transcription Factor AP-2
Mol. Cell. Biol., November 15, 2002; 22(22): 7877 - 7888.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. M. Fedorov, O. Yu. Tyrsin, T. Papadopoulos, G. Camarero, R. Gotz, and U. R. Rapp
Bcl-2 Determines Susceptibility to Induction of Lung Cancer by Oncogenic CRaf
Cancer Res., November 1, 2002; 62(21): 6297 - 6303.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S. H. Meterissian, M. Kontogiannea, M. Al-Sowaidi, A. Linjawi, F. Halwani, B. Jamison, and M. Edwardes
Bcl-2 Is a Useful Prognostic Marker in Dukes' B Colon Cancer
Ann. Surg. Oncol., July 1, 2001; 8(6): 533 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Laudanski, W. Niklinska, T. Burzykowski, L. Chyczewski, and J. Niklinski
Prognostic significance of p53 and bcl-2 abnormalities in operable non-small cell lung cancer
Eur. Respir. J., April 1, 2001; 17(4): 660 - 666.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. C. Turner, S. Krajewski, M. Krajewska, S. Takayama, A. A. Gumbs, D. Carter, T. R. Rebbeck, B. G. Haffty, and J. C. Reed
BAG-1: A Novel Biomarker Predicting Long-Term Survival in Early-Stage Breast Cancer
J. Clin. Oncol., February 15, 2001; 19(4): 992 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. W. Wong, A. Lee, L. Shientag, J. Yu, Y. Dong, G. Kao, A. B. Al-Mehdi, E. J. Bernhard, and R. J. Muschel
Apoptosis: An Early Event in Metastatic Inefficiency
Cancer Res., January 1, 2001; 61(1): 333 - 338.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
S. Whitman, X. Wang, R. Shalaby, and E. Shtivelman
Alternatively Spliced Products CC3 and TC3 Have Opposing Effects on Apoptosis
Mol. Cell. Biol., January 15, 2000; 20(2): 583 - 593.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
K. Hishikawa, B. S. Oemar, F. C. Tanner, T. Nakaki, T. F. Luscher, and T. Fujii
Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF-7
J. Biol. Chem., December 24, 1999; 274(52): 37461 - 37466.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. d. L. Coste, A. Mignon, M. Fabre, E. Gilbert, A. Porteu, T. V. Dyke, A. Kahn, and C. Perret
Paradoxical Inhibition of c-myc-induced Carcinogenesis by Bcl-2 in Transgenic Mice
Cancer Res., October 1, 1999; 59(19): 5017 - 5022.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
R. K. Srivastava, C. Y. Sasaki, J. M. Hardwick, and D. L. Longo
Bcl-2–mediated Drug Resistance: Inhibition of Apoptosis by Blocking Nuclear Factor of Activated T Lymphocytes (NFAT)-induced Fas Ligand Transcription
J. Exp. Med., July 19, 1999; 190(2): 253 - 266.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Baekelandt, G. B. Kristensen, J. M. Nesland, C. G. Trope, and R. Holm
Clinical Significance of Apoptosis-Related Factors p53, Mdm2, and Bcl-2 in Advanced Ovarian Cancer
J. Clin. Oncol., July 1, 1999; 17(7): 2061 - 2061.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. A. Sinicrope, J. Hart, H.-A. Hsu, M. Lemoine, F. Michelassi, and L. C. Stephens
Apoptotic and Mitotic Indices Predict Survival Rates in Lymph Node-negative Colon Carcinomas
Clin. Cancer Res., July 1, 1999; 5(7): 1793 - 1804.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Tanabe, H. Nakanishi, H. Maeda, T. Nishioku, K. Hashimoto, S.-Y. Liou, A. Akamine, and K. Yamamoto
A Predominant Apoptotic Death Pathway of Neuronal PC12 Cells Induced by Activated Microglia Is Displaced by A Non-apoptotic Death Pathway Following Blockage of Caspase-3-dependent Cascade
J. Biol. Chem., May 28, 1999; 274(22): 15725 - 15731.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. B. Poommipanit, B. Chen, and Z. N. Oltvai
Interleukin-3 Induces the Phosphorylation of a Distinct Fraction of Bcl-2
J. Biol. Chem., January 8, 1999; 274(2): 1033 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. W. Dawson, J. Dawson, R. Jones, K. Ward, and L. S. Young
Functional Differences between BHRF1, the Epstein-Barr Virus-Encoded Bcl-2 Homologue, and Bcl-2 in Human Epithelial Cells
J. Virol., November 1, 1998; 72(11): 9016 - 9024.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. J. Uhlmann, T. Subramanian, C. A. Vater, R. Lutz, and G. Chinnadurai
A Potent Cell Death Activity Associated with Transient High Level Expression of BCL-2
J. Biol. Chem., July 10, 1998; 273(28): 17926 - 17932.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. K. Srivastava, A. R. Srivastava, S. J. Korsmeyer, M. Nesterova, Y. S. Cho-Chung, and D. L. Longo
Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase
Mol. Cell. Biol., June 1, 1998; 18(6): 3509 - 3517.
[Abstract] [Full Text]

Home page
 BloodHome page
R. D. Gascoyne, M. Krajewska, S. Krajewski, J. M. Connors, and J. C. Reed
Prognostic Significance of Bax Protein Expression in Diffuse Aggressive Non-Hodgkin's Lymphoma
Blood, October 15, 1997; 90(8): 3173 - 3178.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. D. Gascoyne, S. A. Adomat, S. Krajewski, M. Krajewska, D. E. Horsman, A. W. Tolcher, S. E. O'Reilly, P. Hoskins, A. J. Coldman, J. C. Reed, et al.
Prognostic Significance of Bcl-2 Protein Expression and Bcl-2 Gene Rearrangement in Diffuse Aggressive Non-Hodgkin's Lymphoma
Blood, July 1, 1997; 90(1): 244 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Borner and C. Borner
Diminished Cell Proliferation Associated with the Death-protective Activity of Bcl-2
J. Biol. Chem., May 31, 1996; 271(22): 12695 - 12698.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1994 by the American Association for Cancer Research.