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Cytogenetic Characterization of Tenosynovial Giant Cell Tumors (Nodular Tenosynovitis)¹

The Center for Human Genetics [P. D. C., H. V. D. B.], and Department of Pathology [R. S., B. V. D.], Orthopedic Surgery [I. S., L. D. S.], and Oncologic Surgery [I. D. W.], University of Leuven, Herestraat 49, 3000 Leuven, Belgium

Chromosome investigation in six localized forms of tenosynovial giant cell tumors, also known as nodular tenosynovitis, revealed an identical translocation between chromosomes 1 and 2, t(1;2)(p11;q35–36) in three tumors, a variant translocation t(1;5)(p11;q22) in a fourth case, and a t(2;16)(q33;q24) in a fifth case. One case showed a normal karyotype. Although morphologically rather uniform, these benign tumors appear to be cytogenetically heterogeneous, but the chromosome changes seem to cluster in 2 regions, 1p11 and 16q24.

¹ This text presents research results of the Belgian Program on Interuniversity Poles of Attraction initiated by the Belgian State, Prime Minister's Office, Science Policy Programming. The scientific responsibility is assumed by its authors.

² To whom requests for reprints should be addressed.

Received 6/ 6/94. Accepted 6/15/94.

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