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Antiproliferative Effects of Enediynes on AIDS-derived Kaposi's Sarcoma Cells¹

Departments of Pathology [J. C., D. D. R., D. J. L.], Medicine [D. D. R.], and Chemistry [K. C. N.], University of California San Diego; Veterans Affairs Medical Center [D. D. R., D. J. L.]; and Department of Chemistry, Scripps Research Institute [W. W., K. C. N.], La Jolla, California 92093-0679

We have investigated the antiproliferative and cytotoxic effects of selected enediynes against three Kaposi's sarcoma (KS) cell lines. The enediynes tested were found to be very potent in inhibiting the growth of KS cells. Treatment with concentrations of 10^-10 M or less were capable of producing 50% inhibition of growth. Furthermore, treatment of KS cells with enediynes induced apoptosis in up to 80% of the cells. This unique class of antitumor agents has therapeutic potential for the treatment of KS.

¹ This work was supported by Grants AI-30457 and AI-29164 from the NIH and by the Research Center for AIDS and HIV Infection of the San Diego Veterans Affairs Medical Center. J. C. is supported by a fellowship from the Commonwealth AIDS Research Committee, Australia.

² To whom requests for reprints should be addressed, at Department of Pathology, University of California at San Diego, 9500 Gilman Drive, Clinical Sciences Building, Room 325, La Jolla, CA 92093-0679.

Received 6/ 8/94. Accepted 6/24/94.