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A Clinical and Epidemiological Study of Human Leukocyte Antigen-DPB Alleles in Hodgkin's Disease¹

ICRF Department of Medical Oncology, St. Bartholomew's Hospital, 45 Little Britain, London ECIA 7BE [A. M. O., J. L., T. A. L.], and Tissue Antigen Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WK2A 3PX [S. T., M. A. F., J. G. B.], United Kingdom

An international study to investigate the role of human leukocyte antigen (HLA)-DPB alleles in Hodgkin's disease was conducted with 17 participating centers in 12 countries. A total of 741 patients and 686 controls were typed using polymerase chain reaction amplification of HLA-DPB alleles and subsequent sequence specific oligonucleotide hybridization. The frequency of HLA-DPB1*0301 was found to be significantly increased in white patients, compared with ethnically matched controls. In this population group, the DPB1*0301 allele is associated with a relative risk of 1.95 (P < 0.01). There was also a significant reduction in the frequency of HLA-DPB1*0401 in patients from Japan and Taiwan (relative risk, 0.15; P < 0.01). Clinical analysis from data on 551 patients demonstrated a significantly inferior remission duration in patients with HLA-DPB1*0901, overall (P < 0.05), and in the Japanese and Taiwanese populations (P = 0.02), where this allele is most prevalent. This analysis suggests an epidemiological as well as a possible prognostic association between HLA-DPB alleles and Hodgkin's disease.

¹ This study was supported by the ICRF. It was conducted as part of the 11th International Histocompatibility Workshop.

² To whom requests for reprints should be addressed, at Department of Medicine, Princess Margaret Hospital, 500 Sherbourne Street, Toronto M4X 1K9, Canada.

³ Collaborators are listed in Table 1.

Received 3/25/94. Accepted 7/22/94.

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