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Ultraviolet Radiation Induces Phosphorylation of the Epidermal Growth Factor Receptor¹

Columbia University, Department of Dermatology, New York, New York 10032

² To whom requests for reprints should be addressed.

Ultraviolet light in solar radiation is responsible for more than 600,000 malignancies each year in the United States alone, making it the most 1 efficient environmental carcinogen known. Ultraviolet radiation-induced direct DNA damage is thought to be responsible for its initiating properties, while the promotional aspects of such radiation are poorly defined and only recently gaining attention. We show here for the first time that physiologically relevant doses of ultraviolet radiation induce phosphorylation of the epidermal growth factor receptor in A431 keratinocytes at tyrosine sites within 30 min. Such alteration of this major signal transduction system is probably an important step in the ultraviolet radiation-induced, epidermal cell-signalling cascade.

¹ These studies were funded by NIH Grant 2 R01 33663, American Cancer Society International Research Grant IRG-177B, and the Lester I. Conrad Foundation.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 11/ 4/93. Accepted 11/26/93.

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