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Transforming Growth Factor β-treated Normal Fibroblasts Eliminate Transformed Fibroblasts by Induction of Apoptosis¹

Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herder-Str. 11, D-79104 Freiburg, Germany

² To whom requests for reprints should be addressed.

Transforming growth factor β (TGF-β) induces normal fibroblasts to perform an inhibitory effect directed against transformed cells (P. Höfler, I. Wehrle, and G. Bauer, Int. J. Cancer, 54: 125–130, 1993). Coculture of normal fibroblasts with transformed cells, either resistant to G 418 or expressing Mx antigen detectable by specific immunofluorescence, allowed discrimination between three theoretical mechanisms of inhibition: irreversible inhibition of proliferation; reversion to the nontransformed phenotype; or elimination of transformed cells. Our data demonstrate that normal fibroblasts treated with TGF-β are able to eliminate transformed cells by induction of apoptosis. Sensitivity against TGF-β-induced elimination seems to be a general feature of in vitro-transformed cell lines. TGF-β-induced elimination of transformed fibroblasts by their untransformed counterparts is proposed as a potential potent control point in carcinogenesis, which may lead to the suppression of transformed cells.

¹ This work was supported by the Deutsche Forschungsgemeinschaft (Grant Ba 626-3).

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 7/22/93. Accepted 11/15/93.

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