This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hall, A. G. Articles by Reid, M. M. Search for Related Content PubMed PubMed Citation Articles by Hall, A. G. Articles by Reid, M. M.

Expression of µ Class Glutathione S-Transferase Correlates with Event-free Survival in Childhood Acute Lymphoblastic Leukemia¹

Leukaemia Research Fund Remission Unit, 4th Floor, Cookson Building, Medical School, Framlington Place [A. G. H.] and Department of Haematology, Royal Victoria Infirmary [A. R. C., M. M. R., J. K.], Newcastle upon Tyne NE2 4HH; Department of Pathology, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH [P. A., A. J. M.]; and Departments of Child Health and Medical Statistics [M. C.], Newcastle upon Tyne, NE2 4HH United Kingdom

Expression of the main classes (, µ, and ) of glutathione S-transferase (GST) was assessed in the blasts of children presenting with acute lymphoblastic leukemia using an immunohistochemical technique. Bone marrow trephine biopsies obtained at presentation from 71 cases were studied (42 boys, 29 girls; age range, 6 months-14 years; median age, 4 years) and expression was correlated with event-free survival. The period of follow-up was 12–108 months, during which time 21 patients (30%) relapsed. All the samples examined were negative for class GST. Samples from 8 patients, all of whom remained in remission at the time of analysis, were found to be negative for class GST at presentation. Samples from 44 (patients were negative for µ class GST (62%); of these, 36 patients (82%) remained in remission. In comparison, of the 27 patients who were positive for µ class GST, only 14 (52%) remained in remission. Analysis of event-free survival demonstrated that expression of µ class GST predicts a 3-fold increased risk of relapse (95% confidence interval, 1.25–7.26). This risk factor appears to be independent of other recognized prognostic factors.

¹ This work was supported by the Leukaemia Research Fund and the Tyneside Leukaemia Research Association.

² To whom requests for reprints should be addressed.

Received 6/ 9/94. Accepted 8/31/94.

This article has been cited by other articles:

				M. F. Okcu, M. Selvan, L.-E Wang, L. Stout, R. Erana, G. Airewele, P. Adatto, K. Hess, F. Ali-Osman, M. Groves, et al. Glutathione S-Transferase Polymorphisms and Survival in Primary Malignant Glioma Clin. Cancer Res., April 15, 2004; 10(8): 2618 - 2625. [Abstract] [Full Text] [PDF]

				W. L. Carroll, D. Bhojwani, D.-J. Min, E. Raetz, M. Relling, S. Davies, J. R. Downing, C. L. Willman, and J. C. Reed Pediatric Acute Lymphoblastic Leukemia Hematology, January 1, 2003; 2003(1): 102 - 131. [Abstract] [Full Text] [PDF]

				M. Krajinovic, D. Labuda, G. Mathonnet, M. Labuda, A. Moghrabi, J. Champagne, and D. Sinnett Polymorphisms in Genes Encoding Drugs and Xenobiotic Metabolizing Enzymes, DNA Repair Enzymes, and Response to Treatment of Childhood Acute Lymphoblastic Leukemia Clin. Cancer Res., March 1, 2002; 8(3): 802 - 810. [Abstract] [Full Text] [PDF]

				P. G. Board, G. Chelvanayagam, L. S. Jermiin, N. Tetlow, H.-F. Tzeng, M. W. Anders, and A. C. Blackburn Identification of Novel Glutathione Transferases and Polymorphic Variants by Expressed Sequence Tag Database Analysis Drug Metab. Dispos., April 1, 2001; 29(4): 544 - 547. [Abstract] [Full Text]

				S. M. Davies, L. L. Robison, J. D. Buckley, T. Tjoa, W. G. Woods, G. A. Radloff, J. A. Ross, and J. P. Perentesis Glutathione S-Transferase Polymorphisms and Outcome of Chemotherapy in Childhood Acute Myeloid Leukemia J. Clin. Oncol., March 1, 2001; 19(5): 1279 - 1287. [Abstract] [Full Text] [PDF]

				M. Stanulla, M. Schrappe, A. M. Brechlin, M. Zimmermann, and K. Welte Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study Blood, February 15, 2000; 95(4): 1222 - 1228. [Abstract] [Full Text] [PDF]

				M.L. den Boer, R. Pieters, K.M. Kazemier, M.M.A. Rottier, C.M. Zwaan, G.J.L. Kaspers, G. Janka-Schaub, G. Henze, U. Creutzig, R.J. Scheper, et al. Relationship Between Major Vault Protein/Lung Resistance Protein, Multidrug Resistance-Associated Protein, P-Glycoprotein Expression, and Drug Resistance in Childhood Leukemia Blood, March 15, 1998; 91(6): 2092 - 2098. [Abstract] [Full Text] [PDF]

				C.-L. Chen, Q. Liu, C.-H. Pui, G. K. Rivera, J. T. Sandlund, R. Ribeiro, W. E. Evans, and M. V. Relling Higher Frequency of Glutathione S-Transferase Deletions in Black Children With Acute Lymphoblastic Leukemia Blood, March 1, 1997; 89(5): 1701 - 1707. [Abstract] [Full Text] [PDF]

				P. G. Board, M. Coggan, G. Chelvanayagam, S. Easteal, L. S. Jermiin, G. K. Schulte, D. E. Danley, L. R. Hoth, M. C. Griffor, A. V. Kamath, et al. Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases J. Biol. Chem., August 4, 2000; 275(32): 24798 - 24806. [Abstract] [Full Text] [PDF]