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[Cancer Research 54, 5501-5507, November 1, 1994]
© 1994 American Association for Cancer Research
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Immunohistochemical Analysis of in Vivo Patterns of Bcl-X Expression1

Stanislaw Krajewski2, Maryla Krajewska2, Ahmed Shabaik, Hong-Gang Wang, Shinji Irie, Linda Fong and John C. Reed3

La Jolla Cancer Research Foundation, Oncogene and Tumor Suppressor Gene Program, La Jolla, California 92037 [S. K., M. K., H-G. W., S. I., L. F., J. C. R.], and University of California at San Diego, Department of Pathology, School of Medicine, San Diego, California 92103-8720 [A. S.]

The in vivo patterns of bcl-X gene expression were assessed in human and mouse tissues using an immunohistochemical approach. Polyclonal antisera were raised against synthetic peptides corresponding to amino acids 46–66 and 61–79 of the human Bcl-X protein and were shown to be specific for detection of human and mouse Bcl-X-L and Bcl-X-S proteins by immunoblotting. Bcl-X immunoreactivity was detected in a wide variety of cell types and was typically present in the cytosol in a punctate pattern suggestive of association with intracellular organelles. Among the cell types with prominent Bcl-X immunostaining were: (a) a variety of neuronal populations in the brain as well as sensory neurons in dorsal root ganglia; (b) cortical (but not medullary) thymocytes and activated lymphocytes and plasma cells in lymph nodes; (c) several types of cells in the bone marrow, including megakaryocytes, red cell precursors, and some types of differentiating myeloid cells; (d) reproductive tissues, including the spermatocytes and spermatids in the testes and germinal epithelium of the ovary; and (e) a variety of epithelial cells including mammary epithelium, the secretory epithelial and basal cells of the prostate, uterine endometrium, gastric and intestinal epithelial cells, renal tubule epithelium, and differentiated keratinocytes in the upper layers of the epidermis but not in the basal cells. In many cases, these patterns of Bcl-X expression were strikingly different from those reported previously for Bcl-2, suggesting that Bcl-X and Bcl-2 regulate cell life and death at different stages of cell differentiation through tissue-specific control of their expression.

1 This work was supported in part by Grant DHP32C from the American Cancer Society and Grant CA-60421 from the NIH/National Cancer Institute. J. C. R. is a Scholar of the Leukemia Society of America.

2 S. K. and M. K. contributed equally to this work.

3 To whom requests for reprints should be addressed, at La Jolla Cancer Research Foundation, 10901 N. Torrey Pines Rd., La Jolla, CA 92037.

Received 7/15/94. Accepted 9/14/94.




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J. A. Dominov, J. J. Dunn, and J. B. Miller
Bcl-2 Expression Identifies an Early Stage of Myogenesis and Promotes Clonal Expansion of Muscle Cells
J. Cell Biol., July 27, 1998; 142(2): 537 - 544.
[Abstract]