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Spatial Heterogeneity in Tumor Perfusion Measured with Functional Computed Tomography at 0.05 µl Resolution¹

Center for Imaging and Pharmaceutical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129-2060 [L. M. H., G. J. H., G. L. W.], and Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 [P. E. G. K., R. K. J.]

High speed (200 ms temporal resolution) functional computed tomography was used to demonstrate tumor vascular heterogenelty with 0.05 µl spatial resolution. Vascular topologies were investigated in 2 human small cell lung cancer lines implanted either s.c. or as a tissue isolated preparation in immunocompromised mice. Peripheral versus central vascular topology was identified in the s.c. and tissue-isolated preparations, respectively. Pharmacokinetic analysis demonstrated that tumor physiology was influenced by cell line (P = 0.016) and not by location (P > 0.6). This new technique has the potential to characterize individual tumors in patients with minimal invasiveness, permitting more detailed prognosis and management.

¹ Supported by R35-CA-56591 to R. K. J.

² L. M. H. and P. E. G. K. contributed equally to this work.

Received 10/ 3/94. Accepted 10/20/94.

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