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Characterization and Localization of the TCL-1 Oncogene Product

Jefferson Cancer Institute and Jefferson Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [T-b. F., L. V., C. M. C.], and Raggio-Italgene, SpA, Via delle Antille 29, Pomezia 00040, Italy [M. G. N., A. F., G. R.]

The TCL-1 gene maps at chromosome 14q32.1 and is activated in T cell leukemias and lymphomas by either chromosome translocations or inversions that juxtapose the TCL-1 gene to the / or the ß locus of the T cell receptor. The open reading frame of the TCL-1 gene, coding for a protein of 114 amino acids, was expressed in bacteria and antisera were raised against it. The antibodies recognized the predicted TCL-1 M_r 14,000 protein product in cells expressing TCL-1 mRNA. Cell fractionation experiments indicated that the TCL-1 protein is present in the microsomal fraction. These results were confirmed by confocal microscopy. The TCL-1 protein has considerable sequence similarities to the product of the MTCP-1 gene on chromosome Xq28, which is involved in T cell lymphoproliferative diseases. Thus, TCL-1 may represent a member of a novel family of genes involved in lymphoid proliferation and/or survival and in T cell malignancies.

Received 11/ 2/94. Accepted 11/10/94.

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