| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Jefferson Cancer Institute and Jefferson Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [T-b. F., L. V., C. M. C.], and Raggio-Italgene, SpA, Via delle Antille 29, Pomezia 00040, Italy [M. G. N., A. F., G. R.]
The TCL-1 gene maps at chromosome 14q32.1 and is activated in T cell leukemias and lymphomas by either chromosome translocations or inversions that juxtapose the TCL-1 gene to the 
/
or the ß locus of the T cell receptor. The open reading frame of the TCL-1 gene, coding for a protein of 114 amino acids, was expressed in bacteria and antisera were raised against it. The antibodies recognized the predicted TCL-1 Mr 14,000 protein product in cells expressing TCL-1 mRNA. Cell fractionation experiments indicated that the TCL-1 protein is present in the microsomal fraction. These results were confirmed by confocal microscopy. The TCL-1 protein has considerable sequence similarities to the product of the MTCP-1 gene on chromosome Xq28, which is involved in T cell lymphoproliferative diseases. Thus, TCL-1 may represent a member of a novel family of genes involved in lymphoid proliferation and/or survival and in T cell malignancies.
Received 11/ 2/94. Accepted 11/10/94.
This article has been cited by other articles:
|
|
 |
|
  G. Despouy, M. Joiner, E. Le Toriellec, R. Weil, and M. H. Stern The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKC{theta} and ERK pathways Blood, December 15, 2007; 110(13): 4406 - 4416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-W. Chen, R. N. Rainey, C. E. Balatoni, D. W. Dawson, J. J. Troke, S. Wasiak, J. S. Hong, H. M. McBride, C. M. Koehler, M. A. Teitell, et al. Mammalian Polynucleotide Phosphorylase Is an Intermembrane Space RNase That Maintains Mitochondrial Homeostasis Mol. Cell. Biol., November 15, 2006; 26(22): 8475 - 8487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Auguin, P. Barthe, C. Royer, M.-H. Stern, M. Noguchi, S. T. Arold, and C. Roumestand Structural Basis for the Co-activation of Protein Kinase B by T-cell Leukemia-1 (TCL1) Family Proto-oncoproteins J. Biol. Chem., August 20, 2004; 279(34): 35890 - 35902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Pekarsky, C. Hallas, and C. M. Croce Molecular Basis of Mature T-Cell Leukemia JAMA, November 14, 2001; 286(18): 2308 - 2314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Narducci, E. Pescarmona, C. Lazzeri, S. Signoretti, A. M. Lavinia, D. Remotti, E. Scala, C. D. Baroni, A. Stoppacciaro, C. M. Croce, et al. Regulation of TCL1 Expression in B- and T-Cell Lymphomas and Reactive Lymphoid Tissues Cancer Res., April 1, 2000; 60(8): 2095 - 2100. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Teitell, M. A. Damore, G. G. Sulur, D. E. Turner, M.-H. Stern, J. W. Said, C. T. Denny, and R. Wall TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues PNAS, August 17, 1999; 96(17): 9809 - 9814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sugimoto, T. Hatakeyama, M. G. Narducci, G. Russo, and M. Isobe Identification of the TCL1/MTCP1-like 1 (TML1) Gene from the Region Next to the TCL1 Locus Cancer Res., May 1, 1999; 59(10): 2313 - 2317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gritti, H. Dastot, J. Soulier, A. Janin, M.-T. Daniel, A. Madani, G. Grimber, P. Briand, F. Sigaux, and M.-H. Stern Transgenic Mice for MTCP1 Develop T-Cell Prolymphocytic Leukemia Blood, July 15, 1998; 92(2): 368 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Stoppa-Lyonnet, J. Soulier, A. Lauge, H. Dastot, R. Garand, F. Sigaux, and M.-H. Stern Inactivation of the ATM Gene in T-Cell Prolymphocytic Leukemias Blood, May 15, 1998; 91(10): 3920 - 3926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Fu, G. C. Du Bois, S. P. Song, I. Kulikovskaya, L. Virgilio, J. L. Rothstein, C. M. Croce, I. T. Weber, and R. W. Harrison Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies PNAS, March 31, 1998; 95(7): 3413 - 3418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Virgilio, C. Lazzeri, R. Bichi, K.-i. Nibu, M. G. Narducci, G. Russo, J. L. Rothstein, and C. M. Croce Deregulated expression of TCL1 causes T cell leukemia in mice PNAS, March 31, 1998; 95(7): 3885 - 3889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Pekarsky, A. Koval, C. Hallas, R. Bichi, M. Tresini, S. Malstrom, G. Russo, P. Tsichlis, and C. M. Croce Tcl1 enhances Akt kinase activity and mediates its nuclear translocation PNAS, March 28, 2000; 97(7): 3028 - 3033. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
