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Sialyl-Tn Antigen Expression Occurs Early during Human Mammary Carcinogenesis and Is Associated with High Nuclear Grade and Aneuploidy

Departments of Breast and Gynecologic Medical Oncology [S-H. C., G. N. H., K. D.], Pathology [A. S.], and Clinical Investigation [W. N. H.], University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

Sialyl-Tn (STn) antigen represents an aberrant glycosylation product of cell surface mucin in adenocarcinomas. We studied its expression in 40 breast carcinomas (35 of which included in situ carcinomas) by performing immunostaining with B72.3 monoclonal antibody. STn expression was observed in 50% of cases and was equally frequent in in situ and in invasive carcinomas. Positive STn staining significantly correlated with high nuclear grade (P = 0.001), aneuploidy (P <0.001) and high S-phase fraction (P = 0.02). No correlation was observed between STn staining and age, menopausal status, presence of invasive component, or hormone receptor positivity. STn staining may provide an objective marker of dedifferentiation of breast tumors and should be investigated further for its prognostic value in breast cancers and as a biomarker of malignant transformation of breast epithelium.

¹ Recipient of a Clinical Oncology Career Development Award from the American Cancer Society. To whom requests for reprints should be addressed, at Department of Breast and Gynecologic Medical Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard/Box 56, Houston, TX 77030.

Received 10/28/94. Accepted 11/ 8/94.

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