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Boron Neutron Capture Therapy: Boron Biodistribution and Pharmacokinetics of Na₂B₁₂H₁₁SH in Patients with Glioblastoma¹

Department of Neurosurgery [K. H., G. P.] and Institute of Pathology [H. R.], Karl-Franzens-University Graz, Graz, Austria

Data on biodistribution and pharmacokinetics of Na₂B₁₂H₁₁SH are few and lack in standardization. This study comprises a uniform series of 10 patients with glioblastoma administered Na₂B₁₂H₁₁SH i.v. 24 h before surgery at a dose level used in earlier therapeutical trials (75 mg/kg body weight). Boron concentrations in tumor, normal brain, peritumoral edematous brain, blood, and urine were determined by inductively coupled plasma-atomic emission spectroscopy 24 h after Na₂B₁₂H₁₁SH administration; boron uptake in tumor (mean, 12.2 µg/g) was sufficiently selective compared to concentrations in normal and edematous brain (1.2 and 2.3 µg/g, respectively). Mean concentration ratio of tumor:blood was slightly above unity. Boron concentration in blood decreased according to an open two-compartment model, mean excretion in urine over 24 h was 81.9%. The only side effect was an inconstant facial flush. Among efforts aiming at an optimized treatment protocol a dose escalation study seems to be justified.

¹ Supported by Grant P9173-Med from the Austrian Science Foundation [F.W.F.].

² To whom requests for reprint should be addressed, at Department of Neurosurgery, Landeskrankenhaus, Auenbruggerplatz 29, A-8036 Graz, Austria.

Received 8/ 3/94. Accepted 11/ 2/94.

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