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Laboratory of Cancer Genetics and the Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, [A. B. M., V. V. V. S. M., R. S. K. C.], and the Institute of Cytology and Preventive Oncology, Indian Council of Medical Research, New Delhi[A. B. M., M. P., P. S.] India
We evaluated a panel of 22 protooncogenes for amplification in 50 primary, untreated squamous cell carcinomas of the uterine cervix. The tumors studied belonged to clinical stages II and III; histologically, the majority of them were moderately to well differentiated. Amplification represented by 5 or more copies was observed for the genes MYCLI, SEA, CCND1, BCL1, and GLI in one case each (2%); HRAS in 2 cases (4%); and ERBB2 in 7 cases (14%). Amplification of ERBB2 ranged from 5 to 68 copies. In addition, 2 tumors with ERBB2 amplification showed additional restriction fragments suggesting possible mutation or rearrangement of the gene. The high incidence of ERBB2 amplification in cervical cancer suggests that this gene may play an important role in tumorigenesis.
1 Supported in part by NIH Grants CA-05826 and CA-56125.
2 To whom requests for reprints should be addressed.
Received 11/ 5/93. Accepted 12/15/93.
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