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Tumor-suppressive Activity of N03 Gene Product in v-src-transformed Rat 3Y1 Fibroblasts¹

Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260 Japan

The expression of the N03 gene was significantly reduced in a variety of transformed cells, compared with that in parental rat 3Y1 fibroblasts. To understand the possible role(s) of its product, we have obtained transfectants expressing N03 gene from v-src-transformed 3Y1 cells. Two clones, which overexpressed N03 mRNA, showed a flatter phenotype, a reduced rate of growth, and a decreased ability to grow in soft agar. One of the clones which maintained N03 expression was completely suppressed in forming tumors in nude mice. These data suggest that the N03 gene product may have a suppressive ability on transformed phenotypes.

¹ This work was supported by a Grant-in-Aid from the Ministry of Health and Welfare for the Comprehensive 10-year Strategy for Cancer Control of Japan.

² To whom requests for reprints should be addressed.

Received 11/22/93. Accepted 12/16/93.

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