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Pyruvate Inhibits Growth of Mammary Adenocarcinoma 13762 in Rats

Clinical Nutrition Unit, Department of Medicine [R. T. S.], Montefiore University Hospital, Pittsburgh, Pennsylvania 15213-2582, Department of Pathology [M. R. C., L. C. C.], Montefiore University Hospital, Pittsburgh, Pennsylvania 15213-2582; Plastic and Reconstructive Surgery Division, Department of Surgery [P. M., S. S. R.], Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213-2582; Department of Clinical Epidemiology and Family Medicine [J. E. J.], University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213-2582

¹ To whom requests for reprints should be addressed, at Montefiore University Hospital, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213-2582.

The growth of implanted mammary adenocarcinoma 13762 was measured in rats consuming a liquid diet (35% fat, 18% protein, 47% carbohydrate) supplemented with pyruvate (37.3 g/liter; n = 13) or maltose-dextrin (placebo; n = 13) for 21 days. Mean tumor diameter, measured on day 11, 14, 18, and 21 subsequent to tumor implantation, was 41, 32, 21, and 19% smaller in the pyruvate group (P < 0.05). When euthanized, tumor weight was also smaller in the pyruvate group: pyruvate = 15.0 ± 2.3 (SEM) g; placebo = 24.9 ± 3.2 g, P < 0.05. Visual inspection of organs suggested decreased lung metastases with pyruvate feeding (P < 0.05). Upon microscopic evaluation of organs, hepatic tumor was found only in the placebo group. We conclude that pyruvate inhibits implanted tumor growth in rats.

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Received 3/ 1/93. Accepted 12/ 6/93.

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