| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
B through the Phosphorylation of IB
on Tyrosine Residues1
Cancer Biology Research Laboratory, Stanford University School of Medicine, Stanford, California 94305-5468
The response of mammalian cells to stress is controlled by transcriptional regulatory proteins such as nuclear factor 
B (NF-B) to induce a wide variety of early response genes. In this report, we show that exposure of cells to hypoxia (0.02% O2) results in IB
degradation, increased NF-B DNA binding activity, and transactivation of a reporter gene construct containing two NF-B DNA binding sites. Pretreatment of cells with protein tyrosine kinase inhibitors and the dominant negative allele of c-Raf-1 (Raf301) inhibited IB degradation, NF-B binding, and transactivation of B reporter constructs by hypoxia. To demonstrate a direct link between changes in the phosphorylation pattern of IB with NF-B activation, we immunoprecipitated IB after varying times of hypoxic exposure and found that its tyrosine phosphorylation status increased during hypoxic exposure. Inhibition of the transfer of tyrosine phosphoryl groups onto IB prevented IB degradation and NF-B binding. In comparison to other activators of NF-B such as phorbol myristate acetate or tumor necrosis factor, we did not detect changes in the tyrosine phosphorylation status of IB following treatment with either of these agents. These results suggest that tyrosine phosphorylation of IB during hypoxia is an important proximal step which precedes its dissociation and degradation from NF-B.
1 This work was supported by Grant CA03353 from the National Cancer Institute to A. J. G. and a NIH Predoctoral Training Grant to A. C. K.
2 To whom requests for reprints should be addressed.
Received 1/14/94. Accepted 2/ 4/94.
This article has been cited by other articles:
|
|
 |
|
  N. Gavalda, H. Gutierrez, and A. M. Davies Developmental switch in NF-{kappa}B signalling required for neurite growth Development, October 15, 2009; 136(20): 3405 - 3412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wan and M. J. Lenardo Specification of DNA Binding Activity of NF-{kappa}B Proteins Cold Spring Harb Perspect Biol, October 1, 2009; 1(4): a000067 - a000067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Tennant, R. V. Duran, H. Boulahbel, and E. Gottlieb Metabolic transformation in cancer Carcinogenesis, August 1, 2009; 30(8): 1269 - 1280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Llacuna, M. Mari, J. M. Lluis, C. Garcia-Ruiz, J. C. Fernandez-Checa, and A. Morales Reactive Oxygen Species Mediate Liver Injury Through Parenchymal Nuclear Factor-{kappa}B Inactivation in Prolonged Ischemia/Reperfusion Am. J. Pathol., May 1, 2009; 174(5): 1776 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Nishimoto, M. Sakata, R. Minekawa, Y. Okamoto, A. Miyake, A. Isobe, T. Yamamoto, T. Takeda, E. Ishida, K. Sawada, et al. Metal Transcription Factor-1 Is Involved in Hypoxia-Dependent Regulation of Placenta Growth Factor in Trophoblast-Derived Cells Endocrinology, April 1, 2009; 150(4): 1801 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Wright, T. Zhuang, P. La, G. Yang, and P. A. Dennery Hyperoxia-induced NF-{kappa}B activation occurs via a maturationally sensitive atypical pathway Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L296 - L306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Aggarwal, R.V. Vijayalekshmi, and B. Sung Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe Clin. Cancer Res., January 15, 2009; 15(2): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Taylor Interdependent roles for hypoxia inducible factor and nuclear factor-{kappa}B in hypoxic inflammation J. Physiol., September 1, 2008; 586(17): 4055 - 4059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Ellen, Q. Ke, P. Zhang, and M. Costa NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states Carcinogenesis, January 1, 2008; 29(1): 2 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. BelAiba, S. Bonello, C. Zahringer, S. Schmidt, J. Hess, T. Kietzmann, and A. Gorlach Hypoxia Up-Regulates Hypoxia-Inducible Factor-1{alpha} Transcription by Involving Phosphatidylinositol 3-Kinase and Nuclear Factor {kappa}B in Pulmonary Artery Smooth Muscle Cells Mol. Biol. Cell, December 1, 2007; 18(12): 4691 - 4697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gallagher, H. Gutierrez, N. Gavalda, G. O'Keeffe, R. Hay, and A. M. Davies Nuclear Factor-{kappa}B Activation via Tyrosine Phosphorylation of Inhibitor {kappa}B-{alpha} Is Crucial for Ciliary Neurotrophic Factor-Promoted Neurite Growth from Developing Neurons J. Neurosci., September 5, 2007; 27(36): 9664 - 9669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhang and R. P. Hill Hypoxia Enhances Metastatic Efficiency in HT1080 Fibrosarcoma Cells by Increasing Cell Survival in Lungs, Not Cell Adhesion and Invasion Cancer Res., August 15, 2007; 67(16): 7789 - 7797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lluis, F. Buricchi, P. Chiarugi, A. Morales, and J. C. Fernandez-Checa Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor-{kappa}B via c-SRC and Oxidant-Dependent Cell Death Cancer Res., August 1, 2007; 67(15): 7368 - 7377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Cummins, E. Berra, K. M. Comerford, A. Ginouves, K. T. Fitzgerald, F. Seeballuck, C. Godson, J. E. Nielsen, P. Moynagh, J. Pouyssegur, et al. Prolyl hydroxylase-1 negatively regulates I{kappa}B kinase-beta, giving insight into hypoxia-induced NF{kappa}B activity PNAS, November 28, 2006; 103(48): 18154 - 18159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Koechlin, F Maltais, D Saey, A Michaud, P LeBlanc, M Hayot, and C Prefaut Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease Thorax, October 1, 2005; 60(10): 834 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vaupel The Role of Hypoxia-Induced Factors in Tumor Progression Oncologist, November 1, 2004; 9(suppl_5): 10 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, G. Shi, W. Xia, C. Kong, S. Zhao, A. F. Gaw, E. Y. Chen, G. P. Yang, A. J. Giaccia, Q.-T. Le, et al. Identification of Hypoxia-Regulated Proteins in Head and Neck Cancer by Proteomic and Tissue Array Profiling Cancer Res., October 15, 2004; 64(20): 7302 - 7310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Javaheri, W. T. Abraham, C. Brown, H. Nishiyama, R. Giesting, and L. E. Wagoner Prevalence of obstructive sleep apnoea and periodic limb movement in 45 subjects with heart transplantation Eur. Heart J., February 1, 2004; 25(3): 260 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Seta and D. E. Millhorn Functional genomics approach to hypoxia signaling J Appl Physiol, February 1, 2004; 96(2): 765 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takada, A. Mukhopadhyay, G. C. Kundu, G. H. Mahabeleshwar, S. Singh, and B. B. Aggarwal Hydrogen Peroxide Activates NF-{kappa}B through Tyrosine Phosphorylation of I{kappa}B{alpha} and Serine Phosphorylation of p65: EVIDENCE FOR THE INVOLVEMENT OF I{kappa}B{alpha} KINASE AND Syk PROTEIN-TYROSINE KINASE J. Biol. Chem., June 20, 2003; 278(26): 24233 - 24241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zou, B. Attuwaybi, and B. C. Kone Effects of NF-kappa B inhibition on mesenteric ischemia-reperfusion injury Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G713 - G721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. von Wolff, S. Stieger, K. Lumpp, J. Bucking, T. Strowitzki, and C.J. Thaler Endometrial interleukin-6 in vitro is not regulated directly by female steroid hormones, but by pro-inflammatory cytokines and hypoxia Mol. Hum. Reprod., December 1, 2002; 8(12): 1096 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Russell and P. J. Tofilon Radiation-induced Activation of Nuclear Factor-kappa B Involves Selective Degradation of Plasma Membrane-associated Ikappa Balpha Mol. Biol. Cell, October 1, 2002; 13(10): 3431 - 3440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Algul, Y. Tando, M. Beil, C. K. Weber, C. Von Weyhern, G. Schneider, G. Adler, and R. M. Schmid Different modes of NF-kappa B/Rel activation in pancreatic lobules Am J Physiol Gastrointest Liver Physiol, August 1, 2002; 283(2): G270 - G281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Pearlstein, M. H. Ali, P. T. Mungai, K. L. Hynes, B. L. Gewertz, and P. T. Schumacker Role of Mitochondrial Oxidant Generation in Endothelial Cell Responses to Hypoxia Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 566 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nishi, K. H. Nishi, and A. C. Johnson Early Growth Response-1 Gene Mediates Up-Regulation of Epidermal Growth Factor Receptor Expression during Hypoxia Cancer Res., February 1, 2002; 62(3): 827 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-Z. Liu, K.-T. Lee, C.-L. Chern, J.-T. Cheng, A. Stern, and L.-Y. Tsai Free Radical-Triggered Hepatic Injury of Experimental Obstructive Jaundice of Rats Involves Overproduction of Proinflammatory Cytokines and Enhanced Activation of Nuclear Factor {kappa}B Ann. Clin. Lab. Sci., October 1, 2001; 31(4): 383 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Burne, A. Elghandour, M. Haq, S. R. Saba, J. Norman, T. Condon, F. Bennett, and H. Rabb IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury J. Leukoc. Biol., August 1, 2001; 70(2): 192 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Aoki, T. Nata, R. Morishita, H. Matsushita, H. Nakagami, K. Yamamoto, K. Yamazaki, M. Nakabayashi, T. Ogihara, and Y. Kaneda Endothelial Apoptosis Induced by Oxidative Stress Through Activation of NF-{kappa}B: Antiapoptotic Effect of Antioxidant Agents on Endothelial Cells Hypertension, July 1, 2001; 38(1): 48 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, Y. Yu, V. A. Golovina, S. S. McDaniel, S. Krick, L. Li, J.-Y. Wang, Lewis. J. Rubin, and J. X.-J. Yuan Chronic hypoxia decreases KV channel expression and function in pulmonary artery myocytes Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L801 - L812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hockel and P. Vaupel Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects J Natl Cancer Inst, February 21, 2001; 93(4): 266 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. T. Bui, A. Livolsi, J.-F. Peyron, and J. H.M. Prehn Activation of Nuclear Factor {kappa}b and bcl-x Survival Gene Expression by Nerve Growth Factor Requires Tyrosine Phosphorylation of I{kappa}B{alpha} J. Cell Biol., February 19, 2001; 152(4): 753 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kroon, P Koolwijk, B van der Vecht, and V. van Hinsbergh Hypoxia in combination with FGF-2 induces tube formation by human microvascular endothelial cells in a fibrin matrix: involvement of at least two signal transduction pathways J. Cell Sci., January 2, 2001; 114(4): 825 - 833. [Abstract] [PDF]
|
|
|
|
 |
|
 N. S. Chandel, W. C. Trzyna, D. S. McClintock, and P. T. Schumacker Role of Oxidants in NF-{kappa}B Activation and TNF-{alpha} Gene Transcription Induced by Hypoxia and Endotoxin J. Immunol., July 15, 2000; 165(2): 1013 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Loftis, C. A. Johanns, A. J. Lechner, and G. M. Matuschak Brief hypoxic stress suppresses postbacteremic NF-kappa B activation and TNF-alpha bioactivity in perfused liver Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R99 - R108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Huang, A. DeGuzman, C. D. Bucana, and I. J. Fidler Nuclear Factor-{{kappa}}B Activity Correlates with Growth, Angiogenesis, and Metastasis of Human Melanoma Cells in Nude Mice Clin. Cancer Res., June 1, 2000; 6(6): 2573 - 2581. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Ogiso, A. Tomida, S. Lei, S. Oura, and T. Tsuruo Proteasome Inhibition Circumvents Solid Tumor Resistance to Topoisomerase II-directed Drugs Cancer Res., May 1, 2000; 60(9): 2429 - 2434. [Abstract] [Full Text]
|
|
|
|
|
|
A. Mukhopadhyay, S. K. Manna, and B. B. Aggarwal Pervanadate-induced Nuclear Factor-kappa B Activation Requires Tyrosine Phosphorylation and Degradation of Ikappa Balpha . COMPARISON WITH TUMOR NECROSIS FACTOR-alpha J. Biol. Chem., March 17, 2000; 275(12): 8549 - 8555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Koong, N. C. Denko, K. M. Hudson, C. Schindler, L. Swiersz, C. Koch, S. Evans, H. Ibrahim, Q. T. Le, D. J. Terris, et al. Candidate Genes for the Hypoxic Tumor Phenotype Cancer Res., February 1, 2000; 60(4): 883 - 887. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Han and C. D. Logsdon CCK stimulates mob-1 expression and NF-kappa B activation via protein kinase C and intracellular Ca2+ Am J Physiol Cell Physiol, February 1, 2000; 278(2): C344 - C351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Denko, C. Schindler, A. Koong, K. Laderoute, C. Green, and A. Giaccia Epigenetic Regulation of Gene Expression in Cervical Cancer Cells by the Tumor Microenvironment Clin. Cancer Res., February 1, 2000; 6(2): 480 - 487. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Das, E. C. Dempsey, D. Bouchey, M. E. Reyland, and K. R. Stenmark Chronic Hypoxia Induces Exaggerated Growth Responses in Pulmonary Artery Adventitial Fibroblasts . Potential Contribution of Specific Protein Kinase C Isozymes Am. J. Respir. Cell Mol. Biol., January 1, 2000; 22(1): 15 - 25. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Dawn, Y.-T. Xuan, Y. Qiu, H. Takano, X.-L. Tang, P. Ping, S. Banerjee, M. Hill, and R. Bolli Bifunctional Role of Protein Tyrosine Kinases in Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Circ. Res., December 3, 1999; 85(12): 1154 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-K. Bae, M.-H. Bae, M.-Y. Ahn, M. J. Son, Y. M. Lee, M.-K. Bae, O.-H. Lee, B. C. Park, and K.-W. Kim Egr-1 Mediates Transcriptional Activation of IGF-II Gene in Response to Hypoxia Cancer Res., December 1, 1999; 59(23): 5989 - 5994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ishibashi, M. Weisbrot-Lefkowitz, K. Reuhl, M. Inouye, and O. Mirochnitchenko Modulation of Chemokine Expression During Ischemia/Reperfusion in Transgenic Mice Overproducing Human Glutathione Peroxidases J. Immunol., November 15, 1999; 163(10): 5666 - 5677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G. Canty Jr, E. M. Boyle Jr, A. Farr, E. N. Morgan, E. D. Verrier, and T. H. Pohlman Oxidative Stress Induces NF-{kappa}B Nuclear Translocation Without Degradation of I{kappa}B{alpha} Circulation, November 9, 1999; 100 (2009): II-361 - II-364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Shi, J. L. Abbruzzese, S. Huang, I. J. Fidler, Q. Xiong, and K. Xie Constitutive and Inducible Interleukin 8 Expression by Hypoxia and Acidosis Renders Human Pancreatic Cancer Cells More Tumorigenic and Metastatic Clin. Cancer Res., November 1, 1999; 5(11): 3711 - 3721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Leeper-Woodford and K. Detmer Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-kappa B expression Am J Physiol Lung Cell Mol Physiol, June 1, 1999; 276(6): L909 - L916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-F. Yan, J. Lu, Y. S. Zou, J. Soh-Won, D. M. Cohen, P. M. Buttrick, D. R. Cooper, S. F. Steinberg, N. Mackman, D. J. Pinsky, et al. Hypoxia-associated Induction of Early Growth Response-1 Gene Expression J. Biol. Chem., May 21, 1999; 274(21): 15030 - 15040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C.M. Siow, H. Sato, and G. E. Mann Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc Res, February 1, 1999; 41(2): 385 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Beraud, W. J. Henzel, and P. A. Baeuerle Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappa B activation PNAS, January 19, 1999; 96(2): 429 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rahman and W. MacNee Role of transcription factors in inflammatory lung diseases Thorax, July 1, 1998; 53(7): 601 - 612. [Full Text]
|
|
|
|
|
|
U. R. Pendurthi, J. T. Williams, and L. V. M. Rao Inhibition of Tissue Factor Gene Activation in Cultured Endothelial Cells by Curcumin : Suppression of Activation of Transcription Factors Egr-1, AP-1, and NF-{kappa}B Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3406 - 3413. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. M. Mazure, E. Y. Chen, K. R. Laderoute, and A. J. Giaccia Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element Blood, November 1, 1997; 90(9): 3322 - 3331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Barbeau, R. Bernier, N. Dumais, G. Briand, M. Olivier, R. Faure, B. I. Posner, and M. Tremblay Activation of HIV-1 Long Terminal Repeat Transcription and Virus Replication via NF-kappa B-dependent and -independent Pathways by Potent Phosphotyrosine Phosphatase Inhibitors, the Peroxovanadium Compounds J. Biol. Chem., May 16, 1997; 272(20): 12968 - 12977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Krejsa, S. G. Nadler, J. M. Esselstyn, T. J. Kavanagh, J. A. Ledbetter, and G. L. Schieven Role of Oxidative Stress in the Action of Vanadium Phosphotyrosine Phosphatase Inhibitors. REDOX INDEPENDENT ACTIVATION OF NF-kappa B J. Biol. Chem., April 25, 1997; 272(17): 11541 - 11549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. MATUSCHAK, C. F. MUNOZ, C. A. JOHANNS, R. RAHMAN, and A. J. LECHNER Upregulation of Postbacteremic TNF-alpha and IL-1alpha Gene Expression by Alveolar Hypoxia/Reoxygenation in Perfused Rat Lungs Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 629 - 637. [Abstract] [Full Text]
|
|
|
|
|
|
J. F. Schmedtje Jr., Y.-S. Ji, W.-L. Liu, R. N. DuBois, and M. S. Runge Hypoxia Induces Cyclooxygenase-2 via the NF-kappa B p65 Transcription Factor in Human Vascular Endothelial Cells J. Biol. Chem., January 3, 1997; 272(1): 601 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ryuto, M. Ono, H. Izumi, S. Yoshida, H. A. Weich, K. Kohno, and M. Kuwano Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor alpha in Human Glioma Cells. POSSIBLE ROLES OF SP-1 J. Biol. Chem., November 8, 1996; 271(45): 28220 - 28228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Wood, J. M. Gleadle, C. W. Pugh, O. Hankinson, and P. J. Ratcliffe The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression. STUDIES IN ARNT-DEFICIENT CELLS J. Biol. Chem., June 21, 1996; 271(25): 15117 - 15123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Singh and B. B. Aggarwal Activation of Transcription Factor NF-kappaB Is Suppressed by Curcumin (Diferuloylmethane) J. Biol. Chem., October 20, 1995; 270(42): 24995 - 25000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Norris and D. E. Millhorn Hypoxia-induced Protein Binding to O(2)-responsive Sequences on the Tyrosine Hydroxylase Gene J. Biol. Chem., October 6, 1995; 270(40): 23774 - 23779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Menon, G. R. Guy, and Y. H. Tan Involvement of a Putative Protein-tyrosine Phosphatase and IkappaB-alpha Serine Phosphorylation in Nuclear Factor kappaB Activation by Tumor Necrosis Factor J. Biol. Chem., August 11, 1995; 270(32): 18881 - 18887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Singh and B. B. Aggarwal Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-[IMAGE]B J. Biol. Chem., May 5, 1995; 270(18): 10631 - 10639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bounou, N. Dumais, and M. J. Tremblay Attachment of Human Immunodeficiency Virus-1 (HIV-1) Particles Bearing Host-encoded B7-2 Proteins Leads to Nuclear Factor-kappa B- and Nuclear Factor of Activated T Cells-dependent Activation of HIV-1 Long Terminal Repeat Transcription J. Biol. Chem., February 23, 2001; 276(9): 6359 - 6369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alvarez-Tejado, S. Naranjo-Suarez, C. Jimenez, A. C. Carrera, M. O. Landazuri, and L. del Peso Hypoxia Induces the Activation of the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway in PC12 Cells. PROTECTIVE ROLE IN APOPTOSIS J. Biol. Chem., June 15, 2001; 276(25): 22368 - 22374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Taylor, G. T. Furuta, K. Synnestvedt, and S. P. Colgan Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia PNAS, October 24, 2000; 97(22): 12091 - 12096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Pearlstein, M. H. Ali, P. T. Mungai, K. L. Hynes, B. L. Gewertz, and P. T. Schumacker Role of Mitochondrial Oxidant Generation in Endothelial Cell Responses to Hypoxia Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 566 - 573. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
