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Genetic Instability of Microsatellite Sequences in Many Non-Small Cell Lung Carcinomas¹

Department of Molecular Biology and Genetics [V. S., D. I. S.] and Division of Hematology/Oncology, Department of Internal Medicine [M. d. M. A., D. I. S.], Wayne State University School of Medicine, Detroit, Michigan 48201, and Department of Pharmacology, University of Pittsburgh School of Medicine and the Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261 [J. S., J. H.]

We have analyzed DNA obtained from 38 lung tumors and normal lung or blood DNA for microsatellite instability. Instability was examined at 10 different microsatellite loci on chromosome 3p, as well as loci on 3q, 11p, 11q, and 13q, and two on Xq. We observed microsatellite instability at one or more loci in 13 of the lung tumors analyzed, and this instability ranged from tumors showing instability in only a single microsatellite to two adenocarcinomas that had alterations in all 16 tested microsatellites. Microsatellite instability could therefore play a significant role in the development of a sizable portion of lung tumors.

¹ This work was supported by NIH Grant CA 48013 (to D. I. S.) and NIH Grant CA 50694 (to J. S.).

² To whom requests for reprints should be addressed, at Division of Hematology/Oncology, Department of Internal Medicine, Wayne State University School of Medicine, 540 East Canfield, Detroit, MI 48201. M. A. was provided support by the Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit (Detroit, MI).

Received 1/10/94. Accepted 3/ 4/94.

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