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Microsatellite Instability and Other Molecular Abnormalities in Non-Small Cell Lung Cancer¹

Queensland Cancer Fund Research Unit, Department of Pathology, University of Queensland Medical School, Herston, Queensland, Australia 4006 [K. M. F.]; Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, Queensland, Australia 4032 [K. M. F., P. V. Z.]; and Department of Haematology and Oncology, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia 3052 [P. J. S.]

Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. Instability of these repeat sequences at multiple genetic loci may result from mismatch repair errors and occur in hereditary nonpolyposis colorectal carcinoma and certain sporadic cancers. In non-small cell lung cancer, we found that microsatellite instability was infrequent, affecting only 7 (6.5%) of 108 cases. Despite being observed in all histological subtypes and at different tumor stages, microsatellite instability most commonly affected only one of the six loci tested on five chromosomal arms. In addition, microsatellite instability was associated with extensive, concurrent molecular changes including K-ras and p53 mutations as well as frequent loss of heterozygosity at chromosomal regions 5q, 8p, 9p, 11p, and 17p.

¹ This work was supported by grants from The Prince Charles Hospital, the Queensland Cancer Fund, and the NH and Medical Research Council (Australia).

² To whom requests for reprints should be addressed.

Received 10/10/94. Accepted 11/15/94.

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