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Endometrial Polyps with Predominant Stromal Component Are Characterized by a t(6;14)(p21;q24) Translocation

Istituto di Biologia Generale [R. V., S. M.], Via Ospedale, 119 09124 Cagliari (Sardinia), Italy, Dipartimento di Citomorfologia, Sezione di Anatomia Patologica [G. F.], and Division Ostetrica e Ginecologica USL 21 [M. A.], Cagliari, Italy

Cytogenetic investigation of endometrial polyps revealed the presence of a t(6;14)(p21;q24) as the sole abnormality in three cases. All tumors showed a histopathological pattern of predominant stromal hyperplasia with scarce representation of glandular elements, suggesting that a cytogenetic subgroup characterized by the t(6;14) translocation can be associated with endometrial polyps with a preponderant component of mesenchymal origin.

¹ To whom requests for reprints should be addressed.

Received 9/29/94. Accepted 11/14/94.

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