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[Cancer Research 55, 34-38, January 1, 1995]
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The Novel Activation of ABL by Fusion to an ets-related Gene, TEL1

Panos Papadopoulos, Susan A. Ridge, Catherine A. Boucher2, Carol Stocking and Leanne M. Wiedemann3

Leukaemia Research Fund Centre at the Institute of Cancer Research, Fulham Road, Chester Beatty Laboratories, London, SW3 6JB, United Kingdom [P. P., S. A. R., C. A. B., L. M. W.], and Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität, Hamburg, Germany [P. P., C. S.]

In human leukemia, activation of the ABL proto-oncogene locus on chromosome 9 most commonly occurs as a result of its fusion to the BCR locus on chromosome 22. The resulting chimeric protein displays an elevated tyrosine kinase activity. We have identified a novel activation of ABL which involves a gene located on chromosome 12, designated TEL. Like BCR, TEL is fused in-frame with ABL and produces a fusion protein with an elevated tyrosine kinase activity when assayed in an immune complex. The amino-terminal sequences of TEL encode a helix-loop-helix motif which may mediate dimerization.

1 This work was supported by the Leukaemia Research Fund of Great Britain and the Deutsche Krebshilfe.

2 Present address: Genetics Unit, Department of Anatomy, Charing Cross and Westminster Medical School, London, United Kingdom.

3 To whom requests for reprints should be addressed.

Received 10/28/94. Accepted 11/16/94.




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