This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Probst-Hensch, N. M. Articles by Lin, H. J. Search for Related Content PubMed PubMed Citation Articles by Probst-Hensch, N. M. Articles by Lin, H. J.

Acetylation Polymorphism and Prevalence of Colorectal Adenomas¹

Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, California 90033 [N. M. P-H., R. W. H., S. A. I.]; Department of Epidemiology, School of Public Health, University of California, Los Angeles, California 90024 [M. P. L.]; Department of Gastroenterology, Kaiser Permanente, Los Angeles, California 90027 [H. D. F.] and Bellflower, California 90706 [E. R. L.]; and Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90502 [C-Y. H., B. K. L., D. B. L., G. T. S., H. J. L.]

Polymorphic N-acetyltransferase (NAT2), an enzyme present in the colon, may affect incidence of colon cancer. Individuals with NAT2 fast acetylator genotypes may have higher colon cancer risks due to faster conversion of certain carcinogens to mutagens. We determined NAT2 genotypes in 447 subjects with distal colon adenomas and in 487 controls. No significant increase in adenoma prevalence among fast acetylators was observed. However, there was a suggestion of ethnic differences in NAT2 effects. For example, white fast acetylators potentially had slightly increased risks for adenomas (odds ratio, 1.29; 95% confidence interval, 0.90–1.84), whereas fast acetylation was potentially protective among blacks (odds ratio, 0.64; 95% confidence interval, 0.32–1.28). The apparent difference between blacks and whites may simply reflect random variation around an overall null effect, or it could represent a real difference. There was preliminary evidence for a possible interaction between NAT2 and the glutathione transferase M1 null genotype. Smokers' adenoma prevalence was 10-fold higher for fast acetylators with the null genotype compared to slow acetylators without the null genotype. Large, multiethnic populations and analysis of combinations of genes for carcinogen metabolism may be needed to further assess the role of NAT2 in colorectal tumorigenesis.

¹ Supported in part by the Swiss League against Cancer (N. M. P-H.) and National Cancer Institute Grants 1R01CA63699 and 1R01CA51923 (R. W. H.). H. J. L. was supported by the UCLA Clinical Nutrition Research Unit, Cancer Research Foundation of America, March of Dimes (Basil O'Connor Awards 5-FY92-1216 and 5-FY93-0995), American Cancer Society Institutional Grant IN/IRG 131N to the Jonsson Comprehensive Cancer Center at UCLA, University of California Cancer Research Coordinating Committee, Wendy Will Case Cancer Fund, and Harbor Collegium at Harbor-UCLA Medical Center.

² To whom requests for reprints should be addressed, at Department of Preventive Medicine, University of Southern California School of Medicine, 1420 San Pablo Street, Los Angeles, CA 90033.

Received 2/ 9/95. Accepted 4/ 3/95.

This article has been cited by other articles:

				C. Lilla, E. Verla-Tebit, A. Risch, B. Jager, M. Hoffmeister, H. Brenner, and J. Chang-Claude Effect of NAT1 and NAT2 Genetic Polymorphisms on Colorectal Cancer Risk Associated with Exposure to Tobacco Smoke and Meat Consumption Cancer Epidemiol. Biomarkers Prev., January 1, 2006; 15(1): 99 - 107. [Abstract] [Full Text] [PDF]

				M. J. Wargovich and J. E. Cunningham Diet, Individual Responsiveness and Cancer Prevention J. Nutr., July 1, 2003; 133(7): 2400S - 2403. [Abstract] [Full Text] [PDF]

				M. M. de Jong, I. M. Nolte, G. J. te Meerman, W. T. A. van der Graaf, E. G. E. de Vries, R. H. Sijmons, R. M. W. Hofstra, and J. H. Kleibeuker Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility Cancer Epidemiol. Biomarkers Prev., November 1, 2002; 11(11): 1332 - 1352. [Abstract] [Full Text] [PDF]

				C. Chen, S. Ricks, D. R. Doody, E.D. Fitzgibbons, P. L. Porter, and S. M. Schwartz N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk Carcinogenesis, December 1, 2001; 22(12): 1993 - 1999. [Abstract] [Full Text] [PDF]

				M. L. Frazier, F. T. O’Donnell, S. Kong, X. Gu, I. Campos, R. Luthra, P. M. Lynch, and C. I. Amos Age-associated Risk of Cancer among Individuals with N-Acetyltransferase 2 (NAT2) Mutations and Mutations in DNA Mismatch Repair Genes Cancer Res., February 1, 2001; 61(4): 1269 - 1271. [Abstract] [Full Text]

				D. W. Hein, M. A. Doll, A. J. Fretland, M. A. Leff, S. J. Webb, G. H. Xiao, U.-S. Devanaboyina, N. A. Nangju, and Y. Feng Molecular Genetics and Epidemiology of the NAT1 and NAT2 Acetylation Polymorphisms Cancer Epidemiol. Biomarkers Prev., January 1, 2000; 9(1): 29 - 42. [Abstract] [Full Text]

				A. Seow, B. Zhao, W.-T. Poh, M. Teh, P. Eng, Y.-T. Wang, W.-C. Tan, E. J.D. Lee, and H.-P. Lee NAT2 slow acetylator genotype is associated with increased risk of lung cancer among non-smoking Chinese women in Singapore Carcinogenesis, September 1, 1999; 20(9): 1877 - 1881. [Abstract] [Full Text] [PDF]

				J. D. Potter Colorectal Cancer: Molecules and Populations J Natl Cancer Inst, June 2, 1999; 91(11): 916 - 932. [Abstract] [Full Text] [PDF]

				J. D. Potter, J. Bigler, L. Fosdick, R. M. Bostick, E. Kampman, C. Chen, T. A. Louis, and P. Grambsch Colorectal Adenomatous and Hyperplastic Polyps: Smoking and N-Acetyltransferase 2 Polymorphisms Cancer Epidemiol. Biomarkers Prev., January 1, 1999; 8(1): 69 - 75. [Abstract] [Full Text]

				D Hickman, J Pope, S D Patil, G Fakis, V Smelt, L A Stanley, M Payton, J D Unadkat, and E Sim Expression of arylamine N-acetyltransferase in human intestine Gut, March 1, 1998; 42(3): 402 - 409. [Abstract] [Full Text] [PDF]

				W. E W ROEDIGER and W. BABIDGE Human colonocyte detoxification Gut, December 1, 1997; 41(6): 731 - 734. [Full Text] [PDF]

				A L Hubbard, D J Harrison, C Moyes, A H Wyllie, C Cunningham, E Mannion, and C A D Smith N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions Gut, August 1, 1997; 41(2): 229 - 234. [Abstract] [Full Text] [PDF]