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Department of Immunology, University of Alberta, Edmonton, Alberta T6G 2H7 [B. A., B. M. L.], and Biomira, Inc., Edmonton, Alberta T6N 1H1 [M. A. R., M. J. K., B. M. L.], Canada
Multiparity has been linked with protection against breast cancer. T cells from biparous women, but not T cells from nulliparous women or men, specifically proliferated in response to core peptide sequences of a human breast cancer-associated mucin (MUC-1). Two of the nulliparous women were retested during the first trimester of their first pregnancy, and their T cells proliferated specifically in response to MUC-1 mucin. These observations support the hypothesis that there is a natural immunization against MUC-1 peptide epitopes during pregnancy which provides some protection against the development of breast cancer. These data also suggest that certain MUC-1 synthetic peptides might be effective components of "vaccines" for therapy or prevention of breast cancer.
1 To whom requests for reprints should be addressed, at Biomira, Inc., Edmonton Research Park, 2011-94 Street, Edmonton, Alberta T6N 1H1, Canada.
Received 3/30/95. Accepted 4/27/95.
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