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Cytokine-producing Mammary Carcinomas in Transgenic Rats Carrying the pX Gene of Human T-Lymphotropic Virus Type I¹

Department of Pathology [S. Y., H. I., H. Y., H. S., K. K., A. W., T. Y.] and Institute for Animal Experimentation [N. K.], Hokkaido University School of Medicine, Kita-15, Nishi-7, Sapporo 060, and Laboratory of Virology, National Cancer Center, Tukiji-5-1-1, Chuo-ku, Tokyo 104 [K. S.], Japan

In two lines of transgenic rats (pX rats) from WKAH and F344 strains and carrying the human T-lymphotropic virus type I pX gene, undifferentiated mammary carcinomas developed predominantly in females starting at about 5 months of age, and there was massive infiltration of granulocytes in the tumor tissue. The incidence of the tumor reached about 40% when the rats were 12 months old. mRNAs of both pX and host genes Gro and MIP-2, which are granulocyte chemoattractants of the interleukin 8 family, were highly expressed in the tumor tissue. Since expression and point mutation of several oncogenes and the antioncogene were not demonstrated, hitherto unidentified novel oncogenic pathways may be transactivated by the pX transgene in these pX rats.

¹ This work was supported by grants from the Ministries of Education, Health and Welfare, and Science and Technology of Japan.

² To whom requests for reprints should be addressed.

Received 3/21/95. Accepted 5/ 4/95.

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