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Departments of Pathology [C. C., S. B.] and Medicine [H. W. H.], McMaster University, Hamilton, Ontario L8N 3Z5, and Department of Surgery, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada [K. H., S. G.]
Shortening of telomeres may contribute to the control of the proliferative capacity of normal cells, and telomerase, the enzyme that elongates telomeric DNA, may be essential for unlimited cell proliferation. We have shown previously that telomerase activity is present in human cells immortalized in vitro and in metastatic ovarian carcinoma cells but is undetectable in normal cultured cells or normal tissues. We have determined the temporal pattern of telomerase activity during colorectal carcinogenesis in man. We report that telomerase activity is associated with acquisition of malignancy as it is detectable in colorectal carcinoma but not in adenomatous polyps. Mutations leading to reactivation or upregulation of the enzyme may represent an additional required event in the multistep development of colorectal cancer.
1 This work was supported by a grant from the Medical Research Council of Canada (S. B.) and the National Cancer Institute of Canada (S. G.). C. C. was the recipient of a Fellowship from Institut National de la Santé et de la Recherche Médicale (France), and S. B. will be a Terry Fox Cancer Research Scientist of the National Cancer Institute of Canada until the impending termination of this Award Program by the agency.
2 To whom requests for reprints should be addressed, at Department of Pathology, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
Received 4/ 3/95. Accepted 5/ 5/95.
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