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Department of Cellular and Molecular Biology [H. T., T. I.], First Department of Internal Medicine [M. K., R. N., T. N., G. K.], and First Department of Pathology [E. T.], Hiroshima University School of Medicine, Kasumi 1-2-3, Hiroshima City 734, Japan, and Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9039 [J. W. S.]
Telomerase activity was examined in 105 frozen samples from human normal liver tissues, chronic liver disease, and hepatocellular carcinoma (HCC). Telomerase activity was positive in 28 of 33 HCC tissues regardless of tumor stage or size. Telomerase was expressed in 15 of 18 differentiated HCC nodules smaller than 3 cm. HCC tissues from all eight hepatitis B virus-positive patients were telomerase positive, while telomerase activity was not detected in normal liver tissues (0 of 4). Weak telomerase activity was only detected in 1 of 22 nontumor liver tissues from HCC patients. Interestingly, in 19 of 38 hepatitis tissues and 6 of 8 cirrhotic liver tissues from apparently cancer-free patients, very weak telomerase activity was detected. These results indicate that the expression of telomerase may play a crucial role in hepatocarcinogenesis.
1 Supported in part by Grants-in-Aid for Cancer Research from the Ministry of Education, Science, and Culture of Japan.
2 To whom requests for reprints should be addressed.
Received 3/20/95. Accepted 5/18/95.
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