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Definition and Refinement of Chromosome 11 Regions of Loss of Heterozygosity in Breast Cancer: Identification of a New Region at 11q23.3¹

Jefferson Cancer Institute and Jefferson Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [M. N., D. R., S. R., S. S., S. L. C., A. L. R., G. F. S., C. M. C.]; Ludwig Institute for Cancer Research, University of California at San Diego, LaJolla, California 92093 [G. M. H., W. K. C.]; and Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel [Y. S.]

Chromosome 11 is frequently altered in several types of human neoplasms. In breast cancer, loss of heterozygosity has been described in two regions of this chromosome, 11p15 and 11q22–23. In this report we have dissected the two regions using high-density polymorphic markers, and have found that there are at least two independent areas of loss of heterozygosity in each region, suggesting that multiple genes on chromosome 11 may be targets of genetic alteration during tumor establishment or progression. The regions defined are: at 11p15, between loci D11S576 and D11S1318 and between D11S988 and D11S1318; at 11q23, between D11S2000 and D11S897 and between D11S528 and D11S990. The narrowing of these regions of loss should facilitate the cloning of the regions in yeast artificial chromosomes to identify the critical tumor suppressor genes.

¹ This work was supported by an Outstanding Investigator Award CA39860 from the National Cancer Institute to C. M. C.

² To whom requests for reprints should be addressed, at Thomas Jefferson University, Jefferson Cancer Institute, Bluemle Life Science Building, Room 1035, 233 South 10th Street, Philadelphia, PA 19107-5799.

Received 5/11/95. Accepted 6/ 1/95.

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