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Departments of Immunology [K. T., S. S., K. I.], Urology [M. N.], Neurosurgery [M. H.], and Pediatrics and Child Health [K. T.], Kurume University School of Medicine, 67 Asahi-machi, Kurume 830, Japan
The MAGE genes encoding tumor rejection antigens recognized by CTLs are expressed at the mRNA level in various cancers and in the testis but not in the other normal tissues. The expression of MAGE-1 or MAGE-4 protein in the testicular cells was studied immunohistochemically with the antibodies to the recombinant MAGE-1 or MAGE-4 protein. Both proteins were identified in the nucleus and cytoplasm of spermatogonia and in primary spermatocytes but not in spermatids or Sertoli's cells. Therefore, MAGE proteins are normal tissue antigens compartmentalized in particular testicular cells playing an important role in the early phase of the spermatogenesis.
1 Supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan, and a grant from the Science Research Promotion Fund of Japan Private School Promotion Foundation.
2 To whom requests for reprints should be addressed, at Department of Immunology, Kurume University School of Medicine, 67 Asahi-machi Kurume 830, Japan.
Received 5/ 1/95. Accepted 6/15/95.
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|
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