This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lazar, V. Articles by Vidaud, M. Search for Related Content PubMed PubMed Citation Articles by Lazar, V. Articles by Vidaud, M.

Expression of Human Chorionic Gonadotropin ß Subunit Genes in Superficial and Invasive Bladder Carcinomas¹

Laboratoire d'lmmunologie des Tumeurs, URA 1484 CNRS, Faculté des Sciences Pharmaceutiques et Biologiques de Paris, 75006 Paris [V. L., A. L., Y. G., J. M. B., D. B., M. V.]; Service d'lmmuno-hématologie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif [V. L., J. M. B., D. B.]; Laboratoire de Physiopathologie du Développement, CNRS-Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris [S. G. D., F. R.]; and Department de Chirurgie, Hôpital Henri Mondor, 51 avenue du Ml. Delattre de Tassigny, 94010 Créteil [S. G. D., D. C.], France

Increased serum levels of human chorionic gonadotropin ß subunit (hCGß) were described previously in patients with bladder cancer. To obtain insight into such production of hCGß, the expression of hCGß 7, 8, 5, and 3 genes in bladder carcinomas and normal urothelia was investigated by reverse transcription PCR. Surprisingly, hCGß mRNAs were detected in both normal urothelial and carcinomatous cells. However, tumor progression was characterized by different patterns of transcription of the hCGß genes; the ß7 gene was the only gene transcribed in normal urothelia and T_a tumors included in this study, whereas in addition to ß 7, genes ß 5, 8, and 3 were transcribed in T₁ to T₄ tumors. Moreover, transcription levels of the latter three genes increased with the stage of the disease. These observations show that dramatic modifications in the expression of hCGß genes accompany progression of bladder carcinomas.

¹ This study was supported by grants from the Association pour la Recherche sur le Cancer, Villejuif, France.

² To whom requests for reprints should be addressed, at Genetique Moleculaire, Faculté de Pharmacie, 4 avenue de l'Observatoir, F75006 Paris, France.

Received 5/15/95. Accepted 7/24/95.

This article has been cited by other articles:

				K. Hotakainen, S. Lintula, B. Ljungberg, P. Finne, A. Paju, U.-H. Stenman, and J. Stenman Expression Of Human Chorionic Gonadotropin {beta}-Subunit Type I Genes Predicts Adverse Outcome In Renal Cell Carcinoma J. Mol. Diagn., November 1, 2006; 8(5): 598 - 603. [Abstract] [Full Text] [PDF]

				K. Rull and M. Laan Expression of {beta}-subunit of HCG genes during normal and failed pregnancy Hum. Reprod., December 1, 2005; 20(12): 3360 - 3368. [Abstract] [Full Text] [PDF]

				P. N. Span, P. Manders, J. J.T.M. Heuvel, C. M.G. Thomas, R. R. Bosch, L. V.A.M. Beex, and C.G.J. Sweep Molecular Beacon Reverse Transcription-PCR of Human Chorionic Gonadotropin-{beta}-3, -5, and -8 mRNAs Has Prognostic Value in Breast Cancer Clin. Chem., July 1, 2003; 49(7): 1074 - 1080. [Abstract] [Full Text] [PDF]

				H. M. Moulton, P. H. Yoshihara, D. H. Mason, P. L. Iversen, and P. L. Triozzi Active Specific Immunotherapy with a {beta}-Human Chorionic Gonadotropin Peptide Vaccine in Patients with Metastatic Colorectal Cancer: Antibody Response Is Associated with Improved Survival Clin. Cancer Res., July 1, 2002; 8(7): 2044 - 2051. [Abstract] [Full Text] [PDF]

				J.-M. Costa, D. Vidaud, I. Laurendeau, M. Vidaud, E. Fressinaud, J.-P. Moisan, A. David, D. Meyer, and J.-M. Lavergne Somatic mosaicism and compound heterozygosity in female hemophilia B Blood, August 15, 2000; 96(4): 1585 - 1587. [Abstract] [Full Text] [PDF]

				E. Baudin, J.-M. Bidart, P. Rougier, V. Lazar, P. Ruffié, J. Ropers, M. Ducreux, F. Troalen, J.-C. Sabourin, E. Comoy, et al. Screening for Multiple Endocrine Neoplasia Type 1 and Hormonal Production in Apparently Sporadic Neuroendocrine Tumors J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 69 - 75. [Abstract] [Full Text]

				A. K. Miller-Lindholm, C. J. LaBenz, J. Ramey, E. Bedows, and R. W. Ruddon Human Chorionic Gonadotropin-{beta} Gene Expression in First Trimester Placenta Endocrinology, December 1, 1997; 138(12): 5459 - 5465. [Abstract] [Full Text] [PDF]