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[Cancer Research 55, 3973-3975, September 15, 1995]
© 1995 American Association for Cancer Research
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Genetic Variability of the Human SRD5A2 Gene: Implications for Prostate Cancer Risk1

Juergen K. V. Reichardt2, Nick Makridakis, Brian E. Henderson, Mimi C. Yu, Malcolm C. Pike and Ronald K. Ross

Department of Biochemistry and Molecular Biology [J. K. V. R., N. M.], Institute for Genetic Medicine [J. K. V. R.], and Department of Preventive Medicine [B. E. H., M. C. Y., M. C. P., R. K. R.], University of Southern California/Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, California 90033-1034

Elevated dihydrotestosterone levels have been suggested to increase the risk of prostate cancer. The human SRD5A2 gene encodes the type II steroid 5{alpha}-reductase, which converts testosterone to the more bioactive compound dihydrotestosterone. We have determined the distribution of a dinucleotide repeat in low-risk Asian-Americans, high-risk African-Americans, and intermediate-risk non-Hispanic Whites. We found this marker to be more polymorphic than previously reported, with some alleles being specific to African-Americans. Genetic variants of the SRD5A2 gene may play a role in predisposition to prostate cancer and in explaining the substantial racial/ethnic variability in risk.

1 This work was supported by NIH Grants CA17054, CA53890, CA54281, and CA68581.

2 To whom requests for reprints should be addressed, at Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, 2011 Zonal Avenue, HMR 413, Los Angeles, CA.

Received 7/14/95. Accepted 8/ 4/95.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1995 by the American Association for Cancer Research.