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Loss of Heterozygosity at Chromosome 11q in Lung Adenocarcinoma: Identification of Three Independent Regions¹

Jefferson Cancer Institute and Jefferson Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [D. R., M. N., C. M. C.], and Istituto Nazionale per la Cura dei Tumori, Milan, 20133 Italy [G. M., T. A. D.]

We examined the pattern of allelic loss in 76 adenocarcinomas of the lung using 14 highly informative microsatellite markers on the long arm of chromosome 11. Loss of heterozygosity was found in 48 of 76 tumors (63%). Three distinct regions of deletion were identified. The first region, the most centromeric, lies between markers D11S940 and CD3D; the second, delimited by markers D11S924 and D11S925, is estimated to be 4 Mb in length, and has never been previously described; a third, more telomeric region, the length of which is also estimated to be in the range of 4 Mb, is bracketed by loci D11S1345 and D11S1328. These findings suggest the presence of at least three tumor suppressor genes on the long arm of chromosome 11, and confirm the relevance of 11q22–24, a region frequently deleted in carcinomas of the breast, ovary, uterine, cervix, colon, and malignant melanoma in the pathogenesis of solid tumors. The characterization of minimal regions of loss could provide the basis for the identification and cloning of the critical genes.

¹ This work was supported by National Cancer Institute Outstanding Investigator Award CA39860 to C. M. C., by a CNR "ACRO" Grant to G. M., and by a AIRC Grant to T. A. D.

² To whom requests for reprints should be addressed, at Thomas Jefferson University, Jefferson Cancer Institute, 223 South 10th Street, Philadelphia, PA 19107-5799.

Received 7/10/95. Accepted 8/ 4/95.

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