This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakao, M. Articles by Itoh, K. Search for Related Content PubMed PubMed Citation Articles by Nakao, M. Articles by Itoh, K.

HLA A2601-restricted CTLs Recognize a Peptide Antigen Expressed on Squamous Cell Carcinoma¹

Department of Immunology [M. N., Y. I., K. I.] and First Department of Surgery [H. Y., Y. T., U. T., T. K.], Kurume University School of Medicine, 67 Asahi-machi, Kurume 830; Department of Genetics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maedashi Higashi Ward, Fukuoka 812 [A. K.]; and Department of Immunology, Kanagawa Cancer Center, 54-2 Nakao-machi Asahi Ward, Yokohama 241 [S. Y.], Japan

The CD4^-CD8⁺ CTL (KE-4 CTL) cell line against autologous tumor cells was established in a patient with esophageal cancer. This KE-4 CTL recognized a peptide antigen on esophageal and lung squamous cell carcinomas in an HLA A2601-restricted manner, as evaluated by cytotoxicity against a panel of tumor cells, transfection experiments with HLA A2601 cDNA, and reconstitution with eluted peptides. None of the normal cells tested was lysed by this CTL. These results suggest the existence of HLA A2601-restricted CTL precursors recognizing a peptide antigen on SCC in a patient with esophageal cancer.

¹ Supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, a grant from the Science Research Promotion Fund of the Japanese Private School Promotion Foundation, and a grant from Fukuoka Cancer Society, Fukuoka, Japan.

² To whom requests for reprints should be addressed.

Received 7/ 6/95. Accepted 8/18/95.

This article has been cited by other articles:

				C. P. Tarassoff, P. M. Arlen, and J. L. Gulley Therapeutic vaccines for prostate cancer. Oncologist, May 1, 2006; 11(5): 451 - 462. [Abstract] [Full Text] [PDF]

				R. Salerno-Goncalves, M. Fernandez-Vina, D. M. Lewinsohn, and M. B. Sztein Identification of a Human HLA-E-Restricted CD8+ T Cell Subset in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain Ty21a Typhoid Vaccine J. Immunol., November 1, 2004; 173(9): 5852 - 5862. [Abstract] [Full Text] [PDF]

				Y. Yoshitake, T. Nakatsura, M. Monji, S. Senju, H. Matsuyoshi, H. Tsukamoto, S. Hosaka, H. Komori, D. Fukuma, Y. Ikuta, et al. Proliferation Potential-Related Protein, an Ideal Esophageal Cancer Antigen for Immunotherapy, Identified Using Complementary DNA Microarray Analysis Clin. Cancer Res., October 1, 2004; 10(19): 6437 - 6448. [Abstract] [Full Text] [PDF]

				U. Toh, H. Yamana, S. Sueyoshi, T. Tanaka, F. Niiya, K. Katagiri, H. Fujita, K. Shirozou, and K. Itoh Locoregional Cellular Immunotherapy for Patients with Advanced Esophageal Cancer Clin. Cancer Res., December 1, 2000; 6(12): 4663 - 4673. [Abstract] [Full Text]

				J. R. Grandis, D. M. Falkner, M. F. Melhem, W. E. Gooding, S. D. Drenning, and P. A. Morel Human Leukocyte Antigen Class I Allelic and Haplotype Loss in Squamous Cell Carcinoma of the Head and Neck: Clinical and Immunogenetic Consequences Clin. Cancer Res., July 1, 2000; 6(7): 2794 - 2802. [Abstract] [Full Text]

				V. Karanikas, J. Lodding, V. C. Maino, and I. F. C. McKenzie Flow Cytometric Measurement of Intracellular Cytokines Detects Immune Responses in MUC1 Immunotherapy Clin. Cancer Res., March 1, 2000; 6(3): 829 - 837. [Abstract] [Full Text]

				M. Nakao, S. Shichijo, T. Imaizumi, Y. Inoue, K. Matsunaga, A. Yamada, M. Kikuchi, N. Tsuda, K. Ohta, S. Takamori, et al. Identification of a Gene Coding for a New Squamous Cell Carcinoma Antigen Recognized by the CTL J. Immunol., March 1, 2000; 164(5): 2565 - 2574. [Abstract] [Full Text] [PDF]

				D. Yang, M. Nakao, S. Shichijo, T. Sasatomi, H. Takasu, H. Matsumoto, K. Mori, A. Hayashi, H. Yamana, K. Shirouzu, et al. Identification of a Gene Coding for a Protein Possessing Shared Tumor Epitopes Capable of Inducing HLA-A24-restricted Cytotoxic T Lymphocytes inCancer Patients Cancer Res., August 1, 1999; 59(16): 4056 - 4063. [Abstract] [Full Text] [PDF]

				Y. Saijo, X. Hong, M. Tanaka, R. Tazawa, S. Q. Liu, K. Saijo, T. Ohno, K. Koike, K. Ohkuda, K. Satoh, et al. Autologous High-Killing Cytotoxic T Lymphocytes against Human Lung Cancer Are Induced Using Interleukin (IL)-1{beta}, IL-2, IL-4, and IL-6: Possible Involvement of Dendritic Cells Clin. Cancer Res., May 1, 1999; 5(5): 1203 - 1209. [Abstract] [Full Text] [PDF]

				S. Shichijo, M. Nakao, Y. Imai, H. Takasu, M. Kawamoto, F. Niiya, D. Yang, Y. Toh, H. Yamana, and K. Itoh A Gene Encoding Antigenic Peptides of Human Squamous Cell Carcinoma Recognized by Cytotoxic T Lymphocytes J. Exp. Med., February 2, 1998; 187(3): 277 - 288. [Abstract] [Full Text] [PDF]