This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fong, K. M. Articles by Smith, P. J. Search for Related Content PubMed PubMed Citation Articles by Fong, K. M. Articles by Smith, P. J.

Loss of Heterozygosity Frequently Affects Chromosome 17q in Non-Small Cell Lung Cancer¹

Queensland Cancer Fund Research Unit, Department of Pathology, University of Queensland Medical School, Herston, Queensland, Australia 4006 [K. M. F., Y. K., M. I., P. J. S.] and Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, Queensland, Australia 4032 [K. M. F., P. V. Z.]

Although the short arm of chromosome 17, which contains the p53 gene, is frequently affected by loss of heterozygosity (LOH) in lung cancer, little is known about similar changes on the long arm. We found that LOH affected one or more of six loci along chromosome 17 in 59% of 102 informative non-small cell lung cancer (NSCLC) cases. Specifically, the frequency of LOH at 17q was 42%, approaching that at 17p (54%), and two distinct 17q regions were implicated. LOH at D17S4 on 17q was more frequent in adenocarcinomas than in squamous cell carcinomas, whereas squamous cell carcinomas had more LOH at 17p than at 17q, findings that indicate molecular genetic heterogeneity between the major NSCLC subtypes. In addition, LOH at 17q correlated with higher T stages and a significantly worse prognosis. In comparison, 25% of cases had mutations of p53 exons 5–8 but these were not associated with stage or survival. The data suggest that independent of p53, there are important tumor suppressor gene(s) on 17q that may influence NSCLC pathogenesis, progression, and survival.

¹ This study was supported by TPCH, the Queensland Cancer Fund, and by a NH and MRC (Australia) Medical Postgraduate Scholarship (K. F.).

² To whom requests for reprints should be addressed.

³ Present address: Department of Hematology and Oncology, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia 3052.

Received 7/13/95. Accepted 8/17/95.

This article has been cited by other articles:

				G. Xinarianos, F. E. McRonald, J. M. Risk, N. L. Bowers, G. Nikolaidis, J. K. Field, and T. Liloglou Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer Hum. Mol. Genet., July 1, 2006; 15(13): 2038 - 2044. [Abstract] [Full Text] [PDF]

				J. E. Larsen, M. L. Colosimo, I. A. Yang, R. Bowman, P. V. Zimmerman, and K. M. Fong CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung Carcinogenesis, March 1, 2006; 27(3): 525 - 532. [Abstract] [Full Text] [PDF]

				R. Danesi, F. De Braud, S. Fogli, T. M. De Pas, A. Di Paolo, G. Curigliano, and M. Del Tacca Pharmacogenetics of Anticancer Drug Sensitivity in Non-Small Cell Lung Cancer Pharmacol. Rev., March 1, 2003; 55(1): 57 - 103. [Abstract] [Full Text] [PDF]

				F. Cave-Riant, B. Cuillerier, M. Beau-Faller, N. Martinet, F. Alla, C. Bronner, A. Schneider, P. Oudet, and M. P. Gaub Association of Genetic Defects in Primary Resected Lung Adenocarcinoma Revealed by Targeted Allelic Imbalance Analysis Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 495 - 502. [Abstract] [Full Text] [PDF]

				M. P. Wong, W. K. Lam, E. Wang, S. W. Chiu, C. L. Lam, and L. P. Chung Primary Adenocarcinomas of the Lung in Nonsmokers Show a Distinct Pattern of Allelic Imbalance Cancer Res., August 1, 2002; 62(15): 4464 - 4468. [Abstract] [Full Text] [PDF]

				K. Miura, E. D. Bowman, R. Simon, A. C. Peng, A. I. Robles, R. T. Jones, T. Katagiri, P. He, H. Mizukami, L. Charboneau, et al. Laser Capture Microdissection and Microarray Expression Analysis of Lung Adenocarcinoma Reveals Tobacco Smoking- and Prognosis-related Molecular Profiles Cancer Res., June 1, 2002; 62(11): 3244 - 3250. [Abstract] [Full Text] [PDF]

				E. Sasatomi, S. D. Finkelstein, J. D. Woods, A. Bakker, P. A. Swalsky, J. D. Luketich, H. C. Fernando, and S. A. Yousem Comparison of Accumulated Allele Loss between Primary Tumor and Lymph Node Metastasis in Stage II Non-small Cell Lung Carcinoma: Implications for the Timing of Lymph Node Metastasis and Prognostic Value Cancer Res., May 1, 2002; 62(9): 2681 - 2689. [Abstract] [Full Text] [PDF]

				S. Zöchbauer-Müller, K. M. Fong, A. K. Virmani, J. Geradts, A. F. Gazdar, and J. D. Minna Aberrant Promoter Methylation of Multiple Genes in Non-Small Cell Lung Cancers Cancer Res., January 1, 2001; 61(1): 249 - 255. [Abstract] [Full Text]

				T. Mitsudomi, N. Hamajima, M. Ogawa, and T. Takahashi Prognostic Significance of p53 Alterations in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis Clin. Cancer Res., October 1, 2000; 6(10): 4055 - 4063. [Abstract] [Full Text]

				D. A. VASSILAKIS, G. SOURVINOS, M. MARKATOS, K. PSATHAKIS, D. A. SPANDIDOS, N. M. SIAFAKAS, and D. BOUROS Microsatellite DNA Instability and Loss of Heterozygosity in Pulmonary Sarcoidosis Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1729 - 1733. [Abstract] [Full Text]

				T. Hashimoto, Y. Tokuchi, M. Hayashi, Y. Kobayashi, K. Nishida, S.-i. Hayashi, Y. Ishikawa, S. Tsuchiya, K. Nakagawa, J.-i. Hayashi, et al. p53 Null Mutations Undetected by Immunohistochemical Staining Predict a Poor Outcome with Early-Stage Non-Small Cell Lung Carcinomas Cancer Res., November 1, 1999; 59(21): 5572 - 5577. [Abstract] [Full Text] [PDF]

				M. Toyota, C. Ho, M. Ohe-Toyota, S. B. Baylin, and J.-P. J. Issa Inactivation of CACNA1G, a T-Type Calcium Channel Gene, by Aberrant Methylation of Its 5' CpG Island in Human Tumors Cancer Res., September 1, 1999; 59(18): 4535 - 4541. [Abstract] [Full Text] [PDF]

				J. Geradts, K. M. Fong, P. V. Zimmerman, R. Maynard, and J. D. Minna Correlation of Abnormal RB, p16ink4a, and p53 Expression with 3p Loss of Heterozygosity, Other Genetic Abnormalities, and Clinical Features in 103 Primary Non-Small Cell Lung Cancers Clin. Cancer Res., April 1, 1999; 5(4): 791 - 800. [Abstract] [Full Text] [PDF]

				D A Spandidos, G Sourvinos, H Kiaris, and J Tsamparlakis Microsatellite instability and loss of heterozygosity in human pterygia Br J Ophthalmol, June 1, 1997; 81(6): 493 - 496. [Abstract] [Full Text] [PDF]