This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fong, K. M. Articles by Smith, P. J. Search for Related Content PubMed PubMed Citation Articles by Fong, K. M. Articles by Smith, P. J.

Tumor Progression and Loss of Heterozygosity at 5q and 18q in Non-Small Cell Lung Cancer¹

Queensland Cancer Fund Research Unit, Department of Pathology, University of Queensland Medical School, Herston, Queensland, Australia 4006 [K. M. F., P. J. S.], and Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, Queensland, Australia 4032 [K. M. F., P. V. Z.]

We investigated the frequency and clinical significance of loss of heterozygosity (LOH) at the APC, MCC, and DCC tumor suppressor gene loci in 108 cases of resected non-small cell lung cancer (NSCLC). LOH at the APC/MCC gene cluster at chromosome 5q21 occurred frequently; it affected 29% of informative NSCLC cases and correlated with a significantly worse survival (P < 0.01). Furthermore, in the subtype most frequently affected (SCC), LOH at 5q not only correlated with a worse survival but also tumor involvement of the mediastinal and/or hilar nodes. In contrast, LOH at the DCC locus at chromosome 18q was far less frequent, occurring in 14% of NSCLC cases, and it was not associated with advanced stage or prognosis. These data suggest that LOH at 5q has a role in determining tumor progression and survival in NSCLC, and may prove to be a clinically useful prognostic indicator.

¹ This work was supported by grants from The Prince Charles Hospital, the Queensland Cancer Fund, and the NH&MRC (Australia).

² To whom requests for reprints should be addressed, at the Queensland Cancer Fund Research Unit, Department of Pathology, University of Queensland Medical School, Herston, Queensland, Australia 4006.

³ Present address: Department of Haematology & Oncology, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia 3052.

Received 11/ 2/94. Accepted 11/30/94.

This article has been cited by other articles:

				J. H. Shin, S. M. Kang, Y. S. Kim, D. H. Shin, J. Chang, S. K. Kim, and S. K. Kim Identification of Tumor Suppressor Loci on the Long Arm of Chromosome 5 in Pulmonary Large Cell Neuroendocrine Carcinoma Chest, October 1, 2005; 128(4): 2999 - 3003. [Abstract] [Full Text] [PDF]

				A. Marchetti, F. Barassi, C. Martella, A. Chella, S. Salvatore, A. Castrataro, F. Mucilli, R. Sacco, and F. Buttitta Down Regulation of High in Normal-1 (HIN-1) is a Frequent Event in Stage I Non-Small Cell Lung Cancer and Correlates with Poor Clinical Outcome Clin. Cancer Res., February 15, 2004; 10(4): 1338 - 1343. [Abstract] [Full Text] [PDF]

				R. Danesi, F. De Braud, S. Fogli, T. M. De Pas, A. Di Paolo, G. Curigliano, and M. Del Tacca Pharmacogenetics of Anticancer Drug Sensitivity in Non-Small Cell Lung Cancer Pharmacol. Rev., March 1, 2003; 55(1): 57 - 103. [Abstract] [Full Text] [PDF]

				E. Sasatomi, S. D. Finkelstein, J. D. Woods, A. Bakker, P. A. Swalsky, J. D. Luketich, H. C. Fernando, and S. A. Yousem Comparison of Accumulated Allele Loss between Primary Tumor and Lymph Node Metastasis in Stage II Non-small Cell Lung Carcinoma: Implications for the Timing of Lymph Node Metastasis and Prognostic Value Cancer Res., May 1, 2002; 62(9): 2681 - 2689. [Abstract] [Full Text] [PDF]

				G. Bepler, A. Gautam, L. M. McIntyre, A. F. Beck, D. S. Chervinsky, Y.-C. Kim, D. M. Pitterle, and A. Hyland Prognostic Significance of Molecular Genetic Aberrations on Chromosome Segment 11p15.5 in Non-Small-Cell Lung Cancer J. Clin. Oncol., March 1, 2002; 20(5): 1353 - 1360. [Abstract] [Full Text] [PDF]

				I. E. Krop, D. Sgroi, D. A. Porter, K. L. Lunetta, R. LeVangie, P. Seth, C. M. Kaelin, E. Rhei, M. Bosenberg, S. Schnitt, et al. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells PNAS, July 24, 2001; (2001) 171138398. [Abstract] [Full Text] [PDF]

				J. O. Boyle, F. Lonardo, J. H. Chang, D. Klimstra, V. Rusch, and E. Dmitrovsky Multiple High-Grade Bronchial Dysplasia and Squamous Cell Carcinoma: Concordant and Discordant Mutations Clin. Cancer Res., February 1, 2001; 7(2): 259 - 266. [Abstract] [Full Text]

				S. Zöchbauer-Müller, K. M. Fong, A. K. Virmani, J. Geradts, A. F. Gazdar, and J. D. Minna Aberrant Promoter Methylation of Multiple Genes in Non-Small Cell Lung Cancers Cancer Res., January 1, 2001; 61(1): 249 - 255. [Abstract] [Full Text]

				T. Tsujiuchi, M. Tsutsumi, Y. Sasaki, N. Murata, and Y. Konishi Mutations of Adenomatous Polyposis Coli and {beta}-Catenin Genes during Progression of Lung Tumors Induced by N-Nitrosobis(2-hydroxypropyl)amine in Rats Cancer Res., December 1, 2000; 60(23): 6611 - 6616. [Abstract] [Full Text]

				X. Zhou, B. L. Kemp, F. R. Khuri, D. Liu, J. J. Lee, W. Wu, W. K. Hong, and L. Mao Prognostic Implication of Microsatellite Alteration Profiles in Early-Stage Non-small Cell Lung Cancer Clin. Cancer Res., February 1, 2000; 6(2): 559 - 565. [Abstract] [Full Text]

				J. Geradts, K. M. Fong, P. V. Zimmerman, R. Maynard, and J. D. Minna Correlation of Abnormal RB, p16ink4a, and p53 Expression with 3p Loss of Heterozygosity, Other Genetic Abnormalities, and Clinical Features in 103 Primary Non-Small Cell Lung Cancers Clin. Cancer Res., April 1, 1999; 5(4): 791 - 800. [Abstract] [Full Text] [PDF]

				I. E. Krop, D. Sgroi, D. A. Porter, K. L. Lunetta, R. LeVangie, P. Seth, C. M. Kaelin, E. Rhei, M. Bosenberg, S. Schnitt, et al. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells PNAS, August 14, 2001; 98(17): 9796 - 9801. [Abstract] [Full Text] [PDF]