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[Cancer Research 55, 249-252, January 15, 1995]
© 1995 American Association for Cancer Research
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The Insulin-like Growth Factor I Receptor: A Key to Tumor Growth?

Renato Baserga

Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Philadelphia 19107

The insulin-like growth factor I receptor (IGF-IR) belongs to the family of transmembrane tyrosine kinase receptors, like the receptors for platelet-derived growth factor, the epidermal growth factor, insulin, and others.

Genetic evidence has shown that the IGF-IR is required for optimal growth in vitro and in vivo. Even more important, however, have been recent findings from several laboratories clearly showing that the IGF-IR is an absolute requirement for the establishment and maintenance of the transformed phenotype, both in vivo and in vitro and in several cell types. These findings indicate that the IGF-IR plays a central role in the mechanism of transformation and, as such, could be a preferred target for therapeutic interventions.

Received 10/21/94. Accepted 11/ 8/94.




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