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The Human Tumor Cell-derived Collagenase Stimulatory Factor (Renamed EMMPRIN) Is a Member of the Immunoglobulin Superfamily¹

Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111

Tumor cell-derived collagenase stimulatory factor, renamed extracellular matrix metalloproteinase inducer (EMMPRIN), is a M_r 58,000 glycoprotein which is located on the outer surface of human tumor cells and which interacts with fibroblasts to stimulate expression of several matrix metalloproteinases in the fibroblasts. In this study, we have used several approaches to isolate a complementary DNA encoding EMMPRIN. Several peptide sequences obtained from the isolated M_r 58,000 glycoprotein are found in the translated complementary DNA clone, verifying its identity. Computer database searches indicate that EMMPRIN is a member of the immunoglobulin superfamily and that the deduced amino acid sequence of EMMPRIN is identical to that recently reported for human basigin and M6 antigen, molecules of previously undetermined biological function.

¹ This work was supported by Grant CA 38817 (to C. B.) from the NIH.

² This article is dedicated to the memory of Dr. Chitra Biswas, who passed away August 26, 1993. Requests for reprints should be addressed to Dr. Bryan Toole at Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111.

³ Present address: Instituto de Investigaciones Biologicas, FCE y N, Universidad Nacional de Mar del Plata, Mar del Plata (7600), Argentina.

⁴ Present address: Department of Biochemistry, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036, Japan.

⁵ Present address: Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan.

Received 8/26/94. Accepted 11/ 9/94.

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